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Block 10 Neuro & Psych > Antidepressants > Flashcards

Flashcards in Antidepressants Deck (2)
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Depression Pathophysiology

Monoamine Hypothesis - deficit in fx or amount of monoamines (DA, NE, Epi, 5-HT, etc)
Neurotrophic Hypothesis - altered neurotrophic and endocrine factors.


Monoamine Physiology

Monoamine transporters
= DA transporter (DAT), (SERT), and (NET)
= reuptake into the pre-synaptic cleft to stop NT action
=> Degradation by MAO (monoamine oxidase)