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Pharm U3 > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

Irreversible inhibitor of MAOa and MAOb used for the treatment of depression, anxiety, PTSD, chronic pain, Enuresis, bulimia, and alcoholism?

A

Tranylcypromine

Phenelzine

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2
Q

What are the side effects of tranylcypromine and phenelzine?

A

HTN crisis–cheese effect–foods rich in tyramine

Serotonin syndrome–MAOi + SSRI

Orthostatic hypotension
Sexual dysfunction
Weight gain
Sedation

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3
Q

What is the mechanism of action of the tricyclic drugs?

A

Block reuptake of NE and 5HT at varying potencies and selectivity

Also variably block (receptors):

  • muscarinic
  • a-adrenergic
  • DA
  • Histamine
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4
Q

Tricyclics used for the treatment of depression, anxiety, PTSD, chronic pain, neurosis, bulimia, and alcoholism and work through blocking the reuptake of NE or 5HT?

A
  • Despramine
  • Imipramine
  • Amitriptyline–also used to prevent tension HAs and Migraines
  • Nortriptyline
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5
Q

What are the side effects of the tricyclic drugs?

A

Sympathomimetic–cardiac arrhythmias and conduction defects

Orthostatic hypotension
Sedation
Seizures

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6
Q

SSRIs that inhibit repute of 5HT and NE to lesser extent. Used for the treatment of depression, anxiety, PTSD, Chronic pain, enuresis, bulimia, alcoholism.

A
  • Fluoxetine–also used for treatment of premenstrual dystrophic disorder –potent P450 inhibitor
  • Paroxetine–potent P450 inhibitor
  • Sertraline
  • Escitalopram
  • Citalopram
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7
Q

What are the side effects of the SSRIs?

A

Serotonin syndrome–+ MAOi

Nausea
Decreased sexual function

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8
Q

What are the two SNRIs that work through inhibiting reuptake of 5HT and NE and are used for the treatment of depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism?

A

Duloxetine

Venlafaxine

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9
Q

Used for the treatment of depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism and maintenance of nicotine abstinence in quitting smoking. Works through blocking DA and NE reuptake?

A

Bupropion

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10
Q

What is the mechanism of action of bupropion?

A

Blocks DA and NE reuptake

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11
Q

5HT2a antagonist and inhibitor of 5HT reuptake used for the treatment of depression, anxiety, PTSD, chronic pain, enuresis, bulimia, and alcoholism?

A

Mirtazapine

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12
Q

What is the major side effect of Bupropion?

A

Lowers seizure threshold

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13
Q

Anti-manic/mood -stabilizing (bipolar) and long-term cluster headache prevention that works through he depletion of secondary messengers IP3 and DAG?

A

Lithium

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14
Q

What are the side effects of lithium?

A

Neurotoxicity
Cardiac toxicity
renal dysfunction

Drowsiness
Weight gain
Tremor
Polydipsia
Polyuria
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15
Q

What is the first side of lithium over dose?

A

Nausea and vomiting

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16
Q

What drugs are contraindicated with lithium use?

A

Indomethacin and Na-depleting diuretics

–these will increase Li concentration in the body

Pharm U3 (11 decks)

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