Antidepressants

Question 1

Fluoxetine

Answer 1

Prozac
SSRI
over 1 week t1/2
-wary of serotonin syndrome at transfer to MAOi
cyp2d6 inhibitor-no TCA, haloperiodol, codeine, olols

Question 2

Paroxetine

Answer 2

Paxil
SSRI
cyp2d6 inhibitor-no TCA, haloperiodol, codeine, olols

Question 3

Sertraline

Answer 3

Zoloft

SSRI

Question 4

Citalopram

Answer 4

SSRI

Question 5

Escitalopram

Answer 5

Lexipro

SSRI

Question 6

Fluvoxamine

Answer 6

SSRI

Question 7

Venlafaxine

Answer 7

Effexor
SNRI
can have htx risk
Cyp2D6

Question 8

Duloxetine

Answer 8

Cymbalta

SNRI

Question 9

Imipramine

Answer 9

TCA

inhibits 5HT reuptake way more than NE

Question 10

Amitriptyline

Answer 10

TCA

Question 11

Clomipramine

Answer 11

TCA

Question 12

Desipramine

Answer 12

TCA

inhibits NE reuptake way more than 5HT

Question 13

Nortriptyline

Answer 13

TCA

Question 14

Trazdone

Answer 14

5HT2 antagonist (post synaptic)=MDD
prodrug

sedative and alpha block

Question 15

Nefazodone

Answer 15

5HT2 antagonist (post synaptic(-for hypnosis and MDD

hepatotox

sedative and alpha block

Question 16

buprioion

Answer 16

Heterocyclic

MDD, smoking cessation

enhances NE and D neurotrans=decrases seizure threshold

Question 17

Mirtazapine

Answer 17

Heterocyclic

MDD, sedation

antagonist at 5HT (pre and post)
antagonist of H1 (why sedative)
antagonist @ presynaptic alpha 2
enhances NE and 5HT release

Question 18

Phenelzine

Answer 18

MAOi-irreversible

MDD unremittable to anything else

htx, hyperthermia, CNS overstm, @tyramine=htx crisis, serotonin syndrome with SSRI, ortho htx

wary of sympathomimitcs=htx crisis

Question 19

Tranylcypromine

Answer 19

MAOi-prolonged

MDD unremittable to anything else

htx, hyperthermia, CNS overstm, @tyramine=htx crisis, serotonin syndrome with SSRI, oath htx

wary of sympathomimitcs=htx crisis

Question 20

5HTR

Answer 20

5HT reuptake receptor

Question 21

SERT

Answer 21

SSRI, TCA, SNRI action

Question 22

NET

Answer 22

SNRI action

Question 23

SSRI uses and mech

important

Answer 23

MDD, anxiety, OCD, PTSD, PMDD, bulimia

targets SERT reuptake receptor and inhibits 5HTR

EPS and Serotonin syndrome with MAOi

Question 24

SNRI use

targets

SSRI adverse and

Answer 24

MDD, chronic pain, fibromyalgia, menopause sx

SERT and NET

anticholinergic (PSNS up), sedation

Question 25

TCA targets use adverse

Answer 25

SERT and NET but mannnnny others (esp alpha1 adrenergic) MDD, chronic pain, OCD all SSRI, alpa block (orthodox htx), muscarinic block, WEIGHT GAIN, arrhythmia

Question 26

serotonin syndrome combos

Answer 26

SSRI/SSNI and MAOi (like lineozoid) SSRI/SSNRI and serotinergic (dextromorphine and St johns wart)

Question 27

Lithium - use - mech - increase t1/2 - adverse effects

Answer 27

BAD reduce NE and DA activity/decrease catecholamine (results in decrease in mania) does inositol regeneration NSAIDS and diuretics decrease clearance tremor is common, thyroid fxn decrease, polydip/uria, inhibits K entry to myocytes