Sedative Hypnotics Flashcards Preview

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Flashcards in Sedative Hypnotics Deck (29)
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1
Q

Alprazolam

A

Xanax

Benno-Acute GAD

2
Q

Chlordiazepoxide

A

Benzo-Acute GAD

3
Q

Clonazepam

A

Klonopin

Benzo-Acute GAD

4
Q

Clorazepate

A

Benzo-Acute GAD

5
Q

Diazepam

A

Valium

Benzo-Acute GAD

6
Q

Lorazepam

A

Benzo-Acute GAD

7
Q

Oxazepam

A

Benzo-Acute GAD

8
Q

Midazolam

A

Benzo-Preoperational sedation

9
Q

Flummazenil

A

Treat Benzo OD

binds to Benzo site on GABAa

short t1/2=MUST READMINISTER

10
Q

GABAa receptor

A

GABA binds and activates

Increase freq of opening and closing the channel

Cl- goes through into cell and hyperpolarizaes=less transmission=sedattion

GABA binds to 2 location, benzos bind to 1

11
Q

Elderly benzo dose

do not give bentos with (4)

A

1/2 normal

anti anxiety/hist/AcH or with EtOH

12
Q

long half-life and withdrawl

A

longer half life, slower elim, less withdrawal

13
Q

Escitalopram

A

lexapro-SSRI

14
Q

Paroxetine

A

SSRI

15
Q

Sertraline

A

Zoloft-SSRI

16
Q

Fluoxetine

A

Prozac-SSRI

17
Q

Duloxetine

A

SNRI

18
Q

Venlafaxine

A

SNRI

19
Q

Buspirone

A

selective anxiolytic effects without sedation, hypnosis, or euphoric

second line cuz don’t know about long term efficacy

5HT1a receptor and brain D2 receptors

no interaction with GABA system=low addition

CYP3A4

Co admin with MAOi causes elevated blood pressure

20
Q

Triazolam

A

Benno-Hypnotic
Increase total sleep time, decrease sleep latency, decrease awakenings
Anticonvulsant/Muscle Relaxant

21
Q

Temazepam

A

Restoril
Benno-Hypnotic
Increase total sleep time, decrease sleep latency, decrease awakenings
Anticonvulsant/Muscle Relaxant

22
Q

Estazolam

A

Benno-Hypnotic
Increase total sleep time, decrease sleep latency, decrease awakenings
Anticonvulsant/Muscle Relaxant

23
Q

Flurazepam

A

Benno-Hypnotic
Increase total sleep time, decrease sleep latency, decrease awakenings
Anticonvulsant/Muscle Relaxant

24
Q

Quazepam

A

Benno-Hypnotic
Increase total sleep time, decrease sleep latency, decrease awakenings
Anticonvulsant/Muscle Relaxant

25
Q

Zaleplon

A
Sonata
Non-benzo hypnotic (still GABAnergic)
Does not increase total sleep time
Decrease time to sleep
Rebound insomnia
Anticonvulsant/Muscle Relaxant
26
Q

Zolpidem

A
Ambion
Non-benzo hypnotic (still GABAnergic)
Increase total sleep time
Decrease time to sleep
rebound insomnia
27
Q

Eszopiclone

A

Lunesta
Non-benzo hypnotic (still GABAnergic)
Increase total sleep time
Decrease time to sleep

28
Q

Ramelteon

A

MT1/MT2 receptor agonist
Decrease sleep latency, increase total sleep time
No dep (not Gaba)

29
Q

Suvorexant

A

orexin antagonist
decrease sleep latency and increase sleep periods
HIGHLY RISK OF DEPENDENCE
amnesic effects