Alprazolam
Xanax
Benno-Acute GAD
Chlordiazepoxide
Benzo-Acute GAD
Clonazepam
Klonopin
Benzo-Acute GAD
Clorazepate
Benzo-Acute GAD
Diazepam
Valium
Benzo-Acute GAD
Lorazepam
Benzo-Acute GAD
Oxazepam
Benzo-Acute GAD
Midazolam
Benzo-Preoperational sedation
Flummazenil
Treat Benzo OD
binds to Benzo site on GABAa
short t1/2=MUST READMINISTER
GABAa receptor
GABA binds and activates
Increase freq of opening and closing the channel
Cl- goes through into cell and hyperpolarizaes=less transmission=sedattion
GABA binds to 2 location, benzos bind to 1
Elderly benzo dose
do not give bentos with (4)
1/2 normal
anti anxiety/hist/AcH or with EtOH
long half-life and withdrawl
longer half life, slower elim, less withdrawal
Escitalopram
lexapro-SSRI
Paroxetine
SSRI
Sertraline
Zoloft-SSRI
Fluoxetine
Prozac-SSRI
Duloxetine
SNRI
Venlafaxine
SNRI
Buspirone
selective anxiolytic effects without sedation, hypnosis, or euphoric
second line cuz don’t know about long term efficacy
5HT1a receptor and brain D2 receptors
no interaction with GABA system=low addition
CYP3A4
Co admin with MAOi causes elevated blood pressure
Triazolam
Benno-Hypnotic
Increase total sleep time, decrease sleep latency, decrease awakenings
Anticonvulsant/Muscle Relaxant
Temazepam
Restoril
Benno-Hypnotic
Increase total sleep time, decrease sleep latency, decrease awakenings
Anticonvulsant/Muscle Relaxant
Estazolam
Benno-Hypnotic
Increase total sleep time, decrease sleep latency, decrease awakenings
Anticonvulsant/Muscle Relaxant
Flurazepam
Benno-Hypnotic
Increase total sleep time, decrease sleep latency, decrease awakenings
Anticonvulsant/Muscle Relaxant
Quazepam
Benno-Hypnotic
Increase total sleep time, decrease sleep latency, decrease awakenings
Anticonvulsant/Muscle Relaxant
Zaleplon
Sonata Non-benzo hypnotic (still GABAnergic) Does not increase total sleep time Decrease time to sleep Rebound insomnia Anticonvulsant/Muscle Relaxant
Zolpidem
Ambion Non-benzo hypnotic (still GABAnergic) Increase total sleep time Decrease time to sleep rebound insomnia
Eszopiclone
Lunesta
Non-benzo hypnotic (still GABAnergic)
Increase total sleep time
Decrease time to sleep
Ramelteon
MT1/MT2 receptor agonist
Decrease sleep latency, increase total sleep time
No dep (not Gaba)
Suvorexant
orexin antagonist
decrease sleep latency and increase sleep periods
HIGHLY RISK OF DEPENDENCE
amnesic effects