Sedative Hypnotics Flashcards Preview

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Flashcards in Sedative Hypnotics Deck (29)
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1

Alprazolam

Xanax

Benno-Acute GAD

2

Chlordiazepoxide

Benzo-Acute GAD

3

Clonazepam

Klonopin

Benzo-Acute GAD

4

Clorazepate

Benzo-Acute GAD

5

Diazepam

Valium

Benzo-Acute GAD

6

Lorazepam

Benzo-Acute GAD

7

Oxazepam

Benzo-Acute GAD

8

Midazolam

Benzo-Preoperational sedation

9

Flummazenil

Treat Benzo OD

binds to Benzo site on GABAa

short t1/2=MUST READMINISTER

10

GABAa receptor

GABA binds and activates

Increase freq of opening and closing the channel

Cl- goes through into cell and hyperpolarizaes=less transmission=sedattion

GABA binds to 2 location, benzos bind to 1

11

Elderly benzo dose

do not give bentos with (4)

1/2 normal

anti anxiety/hist/AcH or with EtOH

12

long half-life and withdrawl

longer half life, slower elim, less withdrawal

13

Escitalopram

lexapro-SSRI

14

Paroxetine

SSRI

15

Sertraline

Zoloft-SSRI

16

Fluoxetine

Prozac-SSRI

17

Duloxetine

SNRI

18

Venlafaxine

SNRI

19

Buspirone

selective anxiolytic effects without sedation, hypnosis, or euphoric

second line cuz don't know about long term efficacy

5HT1a receptor and brain D2 receptors

no interaction with GABA system=low addition

CYP3A4

Co admin with MAOi causes elevated blood pressure

20

Triazolam

Benno-Hypnotic
Increase total sleep time, decrease sleep latency, decrease awakenings
Anticonvulsant/Muscle Relaxant

21

Temazepam

Restoril
Benno-Hypnotic
Increase total sleep time, decrease sleep latency, decrease awakenings
Anticonvulsant/Muscle Relaxant

22

Estazolam

Benno-Hypnotic
Increase total sleep time, decrease sleep latency, decrease awakenings
Anticonvulsant/Muscle Relaxant

23

Flurazepam

Benno-Hypnotic
Increase total sleep time, decrease sleep latency, decrease awakenings
Anticonvulsant/Muscle Relaxant

24

Quazepam

Benno-Hypnotic
Increase total sleep time, decrease sleep latency, decrease awakenings
Anticonvulsant/Muscle Relaxant

25

Zaleplon

Sonata
Non-benzo hypnotic (still GABAnergic)
Does not increase total sleep time
Decrease time to sleep
Rebound insomnia
Anticonvulsant/Muscle Relaxant

26

Zolpidem

Ambion
Non-benzo hypnotic (still GABAnergic)
Increase total sleep time
Decrease time to sleep
rebound insomnia

27

Eszopiclone

Lunesta
Non-benzo hypnotic (still GABAnergic)
Increase total sleep time
Decrease time to sleep

28

Ramelteon

MT1/MT2 receptor agonist
Decrease sleep latency, increase total sleep time
No dep (not Gaba)

29

Suvorexant

orexin antagonist
decrease sleep latency and increase sleep periods
HIGHLY RISK OF DEPENDENCE
amnesic effects