Antidepressants Flashcards Preview

Pharmacology II > Antidepressants > Flashcards

Flashcards in Antidepressants Deck (16):
1

What drug is first line for an uncomplicated, physically healthy outpatient with depression?

SSRI

2

Is it recommended to increase dose or switch agents to get better response?

switch agents

3

How do most antidepressants work?

inhibit transporter molecules allowing more neurotransmitter to stay in the synapse

4

Which two neurotransmitters are associated with depression?

-Serotonin
-Norepinephrine

5

TCA

Ex. Amitryptyline

Indications: MDD, Chronic pain, Enuresis

-have anticholinergic effect

Overdose: arrhythmias, seizures

6

MAO inhibitors

Ex. Phenelzine, Tranylcypronine, Selegiline

Indications:
-MDD (unresponsive to other drugs)
-Anxiety, panic disorder
-Selegiline-Parkinson's Disease

ADE: Hypertension with sympathomimetics
Serotonin syndrome with SSRIs*

7

What do you need to be careful with mixing with MAOIs

several different foods (ex. beer, sardines, MSG, liver, raisins, soy sauce, licorice, etc..)

8

SSRIs

Ex. citalopram, escitalopram, Fluoxetine*, Sertraline

Indications: MDD, anxiety disorder, OCD, PMDD, PTSD, Bulima

Interactions: Warfarin

Toxicities: sexual dysfunction**

9

Which SSRI is associated with QT prolongation at higher doses?

Citalopram (Celexa)

10

What adverse drug reaction is associated with SSRIs

suicidality

11

SNRIs

Ex. Venlafaxine*, duloxetine

Indications:
-MDD
-Pain disorders like fibro
-stress urinary incontinence
-vasomotor sx of menopause

ADE: Venlafaxine can cause HTN.
Duloxetine can cause orthostatic hypotension

12

5-HT2 Receptor Antagonists

Ex. Trazodone, Nefazodone

Indications:
-MDD
-Hypnosis (Trazodone)

Trazodone--> very sedating!*, priaprism

13

Norepinephrine and dopamine Reuptake Inhibitor (NDRI)

Ex. bupropion (Wellbutrin)

ADE: Sezuires esp if hx of seizure, alcohol withdrawal, head trauma, CNS tumor

14

Mirtazapine ADE

weight gain

15

How long should an SSRI be continued for MDD maintainence?

12-36 months

16

St. John's Wort

Induces hepatic metabolic enzymes so is associated with significant drug interactions.