Flashcards in Antidepressants Deck (16):
What drug is first line for an uncomplicated, physically healthy outpatient with depression?
Is it recommended to increase dose or switch agents to get better response?
How do most antidepressants work?
inhibit transporter molecules allowing more neurotransmitter to stay in the synapse
Which two neurotransmitters are associated with depression?
Indications: MDD, Chronic pain, Enuresis
-have anticholinergic effect
Overdose: arrhythmias, seizures
Ex. Phenelzine, Tranylcypronine, Selegiline
-MDD (unresponsive to other drugs)
-Anxiety, panic disorder
ADE: Hypertension with sympathomimetics
Serotonin syndrome with SSRIs*
What do you need to be careful with mixing with MAOIs
several different foods (ex. beer, sardines, MSG, liver, raisins, soy sauce, licorice, etc..)
Ex. citalopram, escitalopram, Fluoxetine*, Sertraline
Indications: MDD, anxiety disorder, OCD, PMDD, PTSD, Bulima
Toxicities: sexual dysfunction**
Which SSRI is associated with QT prolongation at higher doses?
What adverse drug reaction is associated with SSRIs
Ex. Venlafaxine*, duloxetine
-Pain disorders like fibro
-stress urinary incontinence
-vasomotor sx of menopause
ADE: Venlafaxine can cause HTN.
Duloxetine can cause orthostatic hypotension
5-HT2 Receptor Antagonists
Ex. Trazodone, Nefazodone
Trazodone--> very sedating!*, priaprism
Norepinephrine and dopamine Reuptake Inhibitor (NDRI)
Ex. bupropion (Wellbutrin)
ADE: Sezuires esp if hx of seizure, alcohol withdrawal, head trauma, CNS tumor
How long should an SSRI be continued for MDD maintainence?