Skeletal Muscle Relaxants Flashcards Preview

Pharmacology II > Skeletal Muscle Relaxants > Flashcards

Flashcards in Skeletal Muscle Relaxants Deck (9):
1

Spasmolytic Drugs: MOA

CNS - reduce abnormally elevated tone

2

Chronic vs. Acute muscle spasms

Chronic:
A. CNS
-Baclofen
-Cyclobenzaprine*
-Diazepam
-Tizanidine

B. Muscle Action
-Dantrolene
-Botulinum toxin

Acute:
-Cyclobenzaprine*

3

Baclofen

MOA: activates GABA

Uses: cerebral palsy, MS

Route: oral and Intrathecal (into spinal canal)

ADE: sedation, muscle weakness

4

Cyclobenzaprine

MOA: inhibits spinal stretch reflex, antimuscarinic effects

Use: acute spasm due to muscle injury or inflammation

Route: oral

ADE: anti-muscarinic effects, sedation **use at bedtime!

5

Carisprodol (Soma)

-IV
-taper slowly over 14 days*

6

Diazepam

MOA: activates GABA, postsynaptic

Route: oral or IV

Pharmacokinetics: long duration (12-24 hours)

ADE: Idiosyncratic parodoxical effect hyperexcitable/combatitive state***

7

Tizanidine

MOA: alpha 2 agonist

indications: MS, stroke, ALS

ADE: hypotension

8

Dantrolene

MOA: reduces myosin-actin interaction

indications: malignant hyperthermia (IV)**

9

Botulinum toxin

uses:
- cerebral palsy
- MS

duration: 2-3 months