antidepressants

Question 1

Antidepressants: Action

Answer 1

• Increase: Serotonin, NE, DA
• Within synapse
• Adaptive changes in receptor sensitivity (delay in efficacy)

Question 2

SSRI MOA

Answer 2

Increased 5 HT (serotonin) is allowed to attach to all 5 HT receptors; Generally: agonize 5 HT1 and Antagonize 5-HT2

Question 3

SSRI drugs

Answer 3

Fluoxetine
Paroxetine
Sertraline
Fluvoxamine
Citalopram
Escitalopram

Question 4

SSRI and Serotonin Receptor Modulator drugs

Answer 4

Vilazodone

Vortioxetine

Question 5

Withdrawal symptoms of SSRIs

Answer 5

• Dizziness, Ataxia, Flu like symptoms, insomnia and/ or irritability
• Occurs w/n 1-10 days after abrupt cessation of an SSRI and can last up to 2 weeks
• Not life threatening

Question 6

Primary Use of SSRIs

Answer 6

Major Depressive Disorder, Anxiety Disorder (GAD, OCD, Panic disorder, PTSD), Fibromyalgia

Question 7

The types of 5HT receptors and ADE

Answer 7

5-HT1: Headache
5-HT2: Somnolence, Sexual Dysfunction
5-HT2c: Weight Gain
5-HT3: Nausea/ Vomiting
5-HT4: Diarrhea

Question 8

Vilazodone MOA

Answer 8

Serotonin Pump Re uptake Inhibitor; Serotonin 1a partial agonist

Question 9

Vilazodone Kinetics

Answer 9

Metabolized by CYP 450; Mod inhibitor of 2D6, 2C19, 2C8

Question 10

Vilazodone ADE

Answer 10

Nausea, Diarrhea, Dizziness, sexual dysfunction

Question 11

Vortioxetine MOA

Answer 11

Serotonin 1a agonist; Serotonin/ Antagonist; 5HT at Receptor 7: decrease cognition

Question 12

Vortioxetine DDIs

Answer 12

Serotonin enhancers, MAOIs

Question 13

Vortioxetine Kinetics

Answer 13

Metabolized by multiple CYP450 paths, 2D6 is primary

Question 14

Vortioxetine ADEs

Answer 14

Nausea, Vomiting, Headache, Dizziness, Sexual Dysfunction