Antidepressants and Antiepileptics

Question 1

Action of antidepressants

Answer 1

Delaying NT reuptake

Inhibiting MAO action

Question 2

Neurotransmitter reuptake inhibitors

Answer 2

Tricyclic antidepressants
SSRI (Selective serotonin reuptake inhibitors)
Other antidepressants (Venlafaxine)

Question 3

Tricyclic antidepressants indications

Answer 3

Antidepressant
Nocturnal pain
Nocturnal enuresis (pipi)
Anorexia
Migraine prophylaxis

Question 4

SSRI indications

Answer 4

First choice antidepressant (bc less ADRs than 3c ad)

Bulimia

Question 5

MAO isoenzymes

Answer 5

MAO A:
More in intestine, unfolds selectively serotonin and noradrenaline
MAO B:
More in brain acts on the metabolism of dopamine

Question 6

Epilepsy cause

Answer 6

Abnormal excessive and hypersynchronous neuronal activity.

Disproportionate temporary neuronal discharge

Question 7

Classification of seizures; Generalized

Answer 7

• Absence seizures (petit mal) brief loss of consciousness no motor movements immobile person
• Tonic-clonic seizures (grand mal) sudden loss of consciousness tonic contraction of all the muscles
• “status epilepticus” Repetition of seizures without recovery of consciousness

Question 8

Classification of seizures; Partial

Answer 8

1. Simple partial seizures:
   No loss of consciousness
   -Motor : mvmts of a member
   -Sensitive: sensory disturbances (auditive and visual)
   -Psychic: cognitive disorders (Hallucinations, delusion)
2. Complex partial seizures:
   Decreased level of consciousness apprears awake but unresponsive. Repetitive automatic mvmts.

Question 9

Drug to eliminate seizures

Answer 9

Diazepam (Valium)

Question 10

2nd generation antiepileptic drugs

Answer 10

Gabapentin

Pregabalin

Question 11

Gingival hyperplasia treatment

Answer 11

Phenytoin