Antidiabeticos

Question 1

Tratamiento diabetes

Answer 1

Oral ADO:
Sulfonilureas
Biguanidas
A cabosa
Tiazolidindionas
Metiglinidas

Parenteral ADP: insulina y analogos

Question 2

Sulfonilureas que son

Answer 2

Secretagogos, hipoglucemiantesnormoglucenicas

Question 3

Mecanismo sulfonilureas

Answer 3

Estimulan celulas B liberar insulina
Mas receptores
Menos glucogenoLISIS

Question 4

Clasificacion sulfonilureas

Answer 4

1 gen
2 gen
3 gen

Question 5

1 gen sulfonilureas

Answer 5

Tolbutamida
Clorpropamida
Tolazamida
Acetohexamida

Question 6

2 gen sulfonilureas

Answer 6

Glicazida

Glibenclamida (glipicida)

Question 7

3 gen sulfonilureas

Answer 7

Glimepirida

Question 8

Sulfonilureas de accion corta

Answer 8

6-12 hrs
Tolbutamida
Acetohexamida

Question 9

Sulfonilureas accion intermedia

Answer 9

12-24 hrs

Glibelnclamida

Question 10

Sulfonilureas accion prolongada

Answer 10

24-72 hrs
Cloropopamida
Glimepirida

Question 11

Sulfonilureas indicaciones

Answer 11

Tipo 2 que no responde a dieta, peso normal

Question 12

Sulfonilureas toxicidad

Answer 12

Alergias fiebres urticaria
Snc
Digestivos
Hepatitis
Anemia
Hipoplasia medula

Question 13

Contraindicaciones sulfonilureas

Answer 13

Hepaticas
Coma
Cetoacidosis
Cirugia
Intolerancia al alcohol con cloropropamida

Question 14

Clasificacion biguanidas

Answer 14

Metformina

Question 15

Accines biguanidas

Answer 15

No disminuyen normoglucemia

Question 16

Mecanismo biguanidas

Answer 16

Consumo histico de glucosa
Inhibe absorcion glucosa
Inhibe glucoNEOgenesis
Mas receptores
Mas utilizacion de glucosa
Glicolisis aerobica
Favorece autofosforilacion de glucosa
Anorexia

Question 17

Indicaciones biguanidas

Answer 17

Dm 2
Obesos que fallo sulfonilureas
Hiperinsulinismo

Question 18

Contraindicaciones biguanidas

Answer 18

Igual que sulfonilureas
Insuf renal, resp, cardi
Embarazo

Question 19

Toxicidad biguanidas

Answer 19

Acidosis lactica

Question 20

A carbosa que es

Answer 20

Origen microbiano

Disminuye posprandial

Question 21

A carbosa mecanismo

Answer 21

Inhibe amilasa alfa pancreatica, alfa glucosidasa

Retarda degradacion y absorcion glucosa

Question 22

Indicaciones a carbosa

Answer 22

Dm2

Question 23

Toxicidad a carbosa

Answer 23

Hipoglucemia

Flatulencia

Question 24

Tiazolidinedionas TZD

Answer 24

Rosiglitazona
Pioglitazona
Acciones 3-4 sem

Question 25

TZD mecanismo

Answer 25

Receptor PPARg (receptor activado por proliferador de peroxisomas gamma) Sensibilizan a insulina Menos glucognesis y glucoNEOgenesis

Question 26

TZD Puede combinarse con

Answer 26

Sulfo y insulina

Question 27

Tzd toxicidad

Answer 27

Hepato

Question 28

Metiglinidas

Answer 28

Repaglinida | Nateglinida

Question 29

Mecanismo metiglinidas

Answer 29

Inhiben canales K Mas ca Desplazan granlos insulina Secretagogos

Question 30

Son secretagogos

Answer 30

Sulfonilureas | Metiglinidas

Question 31

Analogos insulina

Answer 31

Lispro Glargina Aspart

Question 32

Mecanismo insulina

Answer 32

Receptor glut 1-5 Se autofosforila Tarsporte al interior Glucosa a glucosa 6 fosfato luego a ATP para ciclo krebs

Question 33

Isulinas segun tiempo

Answer 33

``` Ultra rap Simple rapida o regular Intermedia Prolongada Ultralenta 30/70 ```

Question 34

Insulina ultra rap Efecto Duracion Indicacion

Answer 34

``` Lispro y aspart Iv 1 min subcut 5 4 hrs Dm1 y dm2 Urgencia ```

Question 35

Simple rapida o regular

Answer 35

``` Humulin Iv 1 min Subcut 30 6 hrs Casos graves: coma cetoacidosis cirugia ```

Question 36

Accion intermedia

Answer 36

``` Insulina nph (neutral protemine hagesorn) Subcut 1 hr 10 hrs Dm 1 Gestacion ```

Question 37

Prolongada

Answer 37

Con zinc protaminda (IZP) Subcut 2 hrs 24 hrs Dm1

Question 38

Ultralenta

Answer 38

``` Glargina Estable Subcut 2 hrs 36 hrs Dm1 y 2 ```

Question 39

30/70

Answer 39

Rapida o reg 30 mas nph 70 Subc 30 min 24 hrs Dm 1 y 2

Question 40

Toxicidad insulina

Answer 40

``` Fenomeno somogy Resistencia infeccion trauma obesidad antiinsulina (cambiar) Lipodistrofia local fibrosis Coma Muerte Urticaria (cambiar insu) Shock ```

Question 41

Fenomeno de somogy

Answer 41

Por insulina | Glucosa se eleva poe adrenalina y glucagon