Antidotes Flashcards Preview

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Flashcards in Antidotes Deck (21):
1

Acetaminophen

N-acetylcysteine (replenishes glutathione)

2

AChE inhibitors (organophosphates)

Atropine followed by pralidoxime (bind to organophosphate-inactivated AChE)

3

Amphetamines

NH4Cl (acidifes urine)

4

Antimuscarinics, anticholinergics

Physostigmine (crosses BBB), control hyperthermia

5

Benzos

Flumazenil

6

Beta blockers

Glucagon

7

Carbon monoxide

Oxygen

8

Copper, arsenic, gold

Penicillamine

9

Cyanide

Nitrites (oxidize hemoglobin to methemoglobin, which more avidly binds cyanide), thiosulfate, hydroxocobalamin

10

Digitalis

Anti-dig Fab fragments

11

Heparin

Protamine sulfate

12

Iron

Deferoxamine, deferasirox

13

Lead

EDTA, dimercaprol, succimer, pencillamine

14

Mercury, arsenic, gold

Dimercaprol (BAL), succimer

15

Methanol, ethyelene glycol (antifreeze)

Fomepizole > ethanol, dialysis

16

Methemoglobin (hemoglobin carries Fe+3)

Methylene blue (helps reduce Fe+3 back to Fe+2), vitamin C

17

Opioids

Naloxone

18

Salicylates

NaHCO3 (alkalinize urine), diaysis

19

TCAs

NaHCO3 (alkalinize plasma)

20

tPA, streptokinase, urokinase

Aminocaproic acid (inhibits plasmin)

21

Warfarin

Vitamin K, FFP