antifungal

Question 1

what antibiotics works in cell synthesis?

Answer 1

-PCN , CPN, carbapenem, aztreonam

-Vancomycin, televancin, Oritevancin

Question 2

• abx with 50 s inbibitor MOA?

Answer 2

Erythromycin
Clarithromyicn
Linezolide/ Tedizolid

Question 3

Abx with 30s MOA

Protein synthesis 30 s Inhibitor

Answer 3

Aminoglycoside
Tetracycline

Question 4

ABX that work on DNA gyrase

Answer 4

Quinolone

Question 5

Abx that works on DNA synthesis

Answer 5

Metronidazole

Question 6

Abx that works on inhibiting transcription of DNA to mRNA

Answer 6

Rifaximin

Question 7

ABX that work on phospholipid membrane

Answer 7

Polymixin B

Question 8

Antifungal that works on cell Nucleic acid Synthesis

Answer 8

Flucytosine

Question 9

Anti-fungal that works on
cell wall

Answer 9

Caspofungin
Anidulafungin (Eraxis)
Ibrexafungerp (Bexafeme)

Question 10

Anti-fungal that works on DECREASING ERGOSTEROL SYNTESHIS AND INHIBITING CELL WALL MEMBRANE

IT WORK ON CYTOCHROME 450 ACTIVITY

Answer 10

AZOLE

Question 11

Antifungal that binds to cell membrane altering membrane permeability

Answer 11

• Amphotericn B

Question 12

Amphotericin B

*AMpho D

Answer 12

MOA:
- Binds to ergosterol

1. SE
   Infusion related shaking chills, hypotension, Nephrotoxicity, dec in K, Mg
2. Dosing conc for infusion
   - **1mg/10mL **
   - Ampho D.. give in Dextrose

Amphotericin in DEXTROSe
Ampho B conc is 1mg/10ml

Question 13

Ampho B lipid forumulation

Answer 13

• Abelcet
• Ambisome
• Amphotec

Question 14

AMpho B lipid form less toxic and must meet one criteria to use Lip formualtion

Answer 14

1. Significant renal imp (CrcL<50 ors Scr>2.4)
2. Patient unable to tolerate regular Ampo
3. Transplant recipient

Question 15

conventional ampho b

Answer 15

1. protect from moisture, light and refrigerated
2. reconstitue w/steriler water then mix with D5W

store in dark at room after reconstituion

Question 16

Azole antifungal

Answer 16

fluconazole
Itraoconazole
voriconazole
ketoconazole
isavuconazonium

Question 17

Azole antifungal

Answer 17

MOA: dec ergosterol synthesis

SE: Hepatoxicity

DUR: CYP450 3A4
- (Inc warfarin)

- itraconazole and ketoconazole need acidic env- take with food

Question 18

Fluconazole

Answer 18

Difulcan
indication
- vaginal candidadis
- Oropharngeal/ esophageal
- Crytococal menigtis

Pregnancy: 150mg is Category C . CDC recom only topical atifungal (vagin

Question 19

Itraconazole

Answer 19

Sporanax

Dose: 200mg PO QD X 12 wks for Onchomycosis

• used for Aspergillus

SE: Hepatoxicity and neg Inotrope

CYP3A4 substrate and Inhib

Question 20

ketoconazole

Answer 20

Nizoral
Form/Indication
- 1% shampoo:
- 2% shampoo for Tinea versicolor
- systemica fungal infection

Needs acidic env
CYP3A4 substrate and inhib

tineas versicolor: discoloration patch of skin; overgrowht of type of ye

Question 21

Voriconazole

Answer 21

VFend
Indication
- Aspergillus
- forms : Tab, Inj, susp
- EMPTY STOMACH

WARNNG
VORICONAZOLE
O: OPTIC (Monitor for vison imp)
O: Photosensitivity
O: QT
C: CNS

cyp3A4 substrate and inhib

Question 22

isavuconazonium

Answer 22

Cresemba
Indication
- Aspergillus
- oral/ IV
- major CYP3A4 substrate

Question 23

Caspofungin

Answer 23

Cancidas
MoA: Inhibits cell wall
Indication
- Aspergillosis
- dilute in NS or lactated ringer

Question 24

Anidalfungin

Answer 24

Eraxis

IV

Question 25

Posconazole

Answer 25

Noxafil MOA: inhibit ergosterol synthesis Indication - prevent/tx invasive aspergillos - oral susp - avoid in renal imp Crcl <50

Question 26

Clotrimazole

Answer 26

- topical for athlete foot - troch lonzes for oral thrush - gyne-lotrimin for vaginal yeast inf - vaginal tablet for vaginal yeast inf

Question 27

Nystatin

Answer 27

Topical and oral oral thrush: swish and swallow

Question 28

terbinafine

Answer 28

Lamisil MOA: inhibits ergosterol synthesis indication - fingernail for 6 wks - toenail for 12 weeks

Question 29

Ciclopirox

Answer 29

Penlac- top solution topical nail lacquer for onchomycosis of fingernails and toenails

Question 30

Efinacazole

Answer 30

Jublia QD for 48 weeks

Question 31

therpy for onchomycosis

Answer 31

PO - terbinafine (lamisi) - itraconazole (Sporonax) Topical - Ciclopirox (Penlac) - Efinacozole (Jublia) - Tea tree oil

Question 32

flucytosine

Answer 32

Ancobon PO synergestic with ampho B or fluconazole in cryptococcal menigntis