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Flashcards in Antifungal Deck (24):
1

What anti-fungal drug is used for systemic, life threatening disease?

What is the target?

Amphotericin B and Nystatin

Ergosterol

2

What are superficial mycoses usually caused by? These are caused by what species of fungi?


Dermatophytes

Candida

3

Epidermophyton
Trichophyton
Microsporum
These fungi are common what?

Dermatophytes

4

Amphotericin B can be given via IV, liposomes, or _______________? Does not penetrate well into the CNS

Intrathecally (given in CNS)

5

What types of effects can Amphotericin B have?

Thrombophlebitis, anaphylaxis, and Convulsions, and anemia

6

What are ways that amphotericin B can be watered down to not make as bad?

slow infusion, hydrate, give with flucytosine, lower overall concentrated dose

7

What are adverse reactions with Flucytosine?

Is normally given with what?

Bone marrow suppression, Hepatic dysfunction, Colitis

Amphotericin B

8

What do -azole drugs block?

What part of the cell wall is blocked?

Ergosterol synthesis, inhibit 14-alpha demethylase, stops lanosterol to ergosterol in the ergosterol synthesis

9

How is the absorption of ketoconazole and itraconazole affected with anatacids and food?

Ketoconazole is decreased by antacids
Itraconzaole is increased with food

10

What is drug is the back up drug used for treatment of mucocutaneous cadidia?

Ketoconazole

11

Ketoconazole has what effects on the endocrine system?

What kind of reation with alcohol?

Androgen and Adrenal Steroid Synthesis

Disulfiram like reaction

12

What drug can cause gyncecomastia, low libido, and impotence?

This same drug inhibits the CYP450 system and can cause an increase or decrease in a lot of other drugs?

Ketoconazole


Increase in levels

13

What is the drug of choice for Cryptococcal meningitis, Candidal infections, Coccidioidomycosis?

Does this drug reach into the CNS?

Fluconazole



Yes

14

What is the azole of choice for Blastomycosis, sporotrichosis, paracoccidiomycosis, and histoplasmosis?

Itraconazole

15

What Itraconazole adverse reactions are there?

Steven Johnson, avoid in pregnancy

16

Voriconazole is the approved treatment for what fungus? What is the main contraindication?


Aspergillosis, twister from sketchy

Transient Visual Disturbance

17

What drug is used for superficial fungi that binds to spindle formation, and inhibits fungi?

Griseofulvin

18

What is the DOC for Tinea Capitis in children for efficacy, safety, and availability as an oral suspension?

What is ADR of this drug?

Griseofulvin


Acute Intermittent porphyria (blood in urine for a minute)

Disulfiram like reaction with alcohol

19

What is the DOC for dermatophytoses, especially onychomycoses (fungal infections of nails/toenails/fingernails)?

Terbinafine

20

What type of drug is Terbinafine?

What is the MOA?

Allymine

Prevents squalene synthesis via squalene epoxidase inhibition

21

What is Terinafine very similar too?

Fungicidal agent

22

What drug is tolerated better than griseofulvin, and is more effective than griseofulvin and itraconazole?

Terbinafine

23

What type of ADR is there with Terbinafine?

What part of this drug works on onychomycosis with 100% response?

Rash, diarrhea, urticaria


Topical and Oral on nails

24

What drug is used instead of Amphotericin B or Itraconazole?

What is the MOA?

Echinocandins/capsofungin

Stops 1,3 Beta glucan synthesis