Flashcards in Antifungal Deck (24):
What anti-fungal drug is used for systemic, life threatening disease?
What is the target?
Amphotericin B and Nystatin
What are superficial mycoses usually caused by? These are caused by what species of fungi?
These fungi are common what?
Amphotericin B can be given via IV, liposomes, or _______________? Does not penetrate well into the CNS
Intrathecally (given in CNS)
What types of effects can Amphotericin B have?
Thrombophlebitis, anaphylaxis, and Convulsions, and anemia
What are ways that amphotericin B can be watered down to not make as bad?
slow infusion, hydrate, give with flucytosine, lower overall concentrated dose
What are adverse reactions with Flucytosine?
Is normally given with what?
Bone marrow suppression, Hepatic dysfunction, Colitis
What do -azole drugs block?
What part of the cell wall is blocked?
Ergosterol synthesis, inhibit 14-alpha demethylase, stops lanosterol to ergosterol in the ergosterol synthesis
How is the absorption of ketoconazole and itraconazole affected with anatacids and food?
Ketoconazole is decreased by antacids
Itraconzaole is increased with food
What is drug is the back up drug used for treatment of mucocutaneous cadidia?
Ketoconazole has what effects on the endocrine system?
What kind of reation with alcohol?
Androgen and Adrenal Steroid Synthesis
Disulfiram like reaction
What drug can cause gyncecomastia, low libido, and impotence?
This same drug inhibits the CYP450 system and can cause an increase or decrease in a lot of other drugs?
Increase in levels
What is the drug of choice for Cryptococcal meningitis, Candidal infections, Coccidioidomycosis?
Does this drug reach into the CNS?
What is the azole of choice for Blastomycosis, sporotrichosis, paracoccidiomycosis, and histoplasmosis?
What Itraconazole adverse reactions are there?
Steven Johnson, avoid in pregnancy
Voriconazole is the approved treatment for what fungus? What is the main contraindication?
Aspergillosis, twister from sketchy
Transient Visual Disturbance
What drug is used for superficial fungi that binds to spindle formation, and inhibits fungi?
What is the DOC for Tinea Capitis in children for efficacy, safety, and availability as an oral suspension?
What is ADR of this drug?
Acute Intermittent porphyria (blood in urine for a minute)
Disulfiram like reaction with alcohol
What is the DOC for dermatophytoses, especially onychomycoses (fungal infections of nails/toenails/fingernails)?
What type of drug is Terbinafine?
What is the MOA?
Prevents squalene synthesis via squalene epoxidase inhibition
What is Terinafine very similar too?
What drug is tolerated better than griseofulvin, and is more effective than griseofulvin and itraconazole?
What type of ADR is there with Terbinafine?
What part of this drug works on onychomycosis with 100% response?
Rash, diarrhea, urticaria
Topical and Oral on nails