Flashcards in Antifungal drugs (3 Q's on the test) Deck (19):
fungi differ from bacteria in that they are eukaryotes and so they have ... ribosomes compared to bacterial ... ribosomes. therefore many antibacterial agents are ineffective
fungi are ... growing and much ... than bacteria
fungi have a ... cell wall instead of ... cell walls in bacteria
fungi contain ... instead of cholesterol (mammalian) in cell membranes. basis of selective action or ... and ...
fungal infections occur in .... ... tissues and they're difficult to treat since antifungals are poorly soluble
poorly vascularized (skin, nails, hair)
fungi cause a cellular ... ... leading to a ... ... which may interfere with drug penetration
immune response (antigens/polysaccharides)
short term, low toxicity therapy for ...
long term thus higher toxicity for ...
Griseofulvin: -static or
-static but can be cidal at high doses
griseofulvin is best taken with a ... ...
fatty meal (poor orally otherwise)
T/F flucytosine is a prodrug
Amphotericin B MOA
binding to ergosterol (makes pores)
Ampho B: cidal or static?
Ampho B is most important for .... infections
Ampho B can increase the uptake of these two drugs:
Ampho B also have synergism with ...
Ampho B has a wide spectrum which makes in #1 for serious systemic fungal infections BUT it has 4 drawbacks:
IV admin only
5-FC is absorbed well orally, soluble, well distributed, not metabolized and has good renal clearance but has the 3 following drawbacks
Azoles- Imidazoles; Triazoles
static or cidal?
static but cidal at high dose