Antifungal drugs (3 Q's on the test) Flashcards Preview

Pharm Exam 4 SP2018 > Antifungal drugs (3 Q's on the test) > Flashcards

Flashcards in Antifungal drugs (3 Q's on the test) Deck (19):
1

fungi differ from bacteria in that they are eukaryotes and so they have ... ribosomes compared to bacterial ... ribosomes. therefore many antibacterial agents are ineffective

80S
70S

2

fungi are ... growing and much ... than bacteria

slow
larger

3

fungi have a ... cell wall instead of ... cell walls in bacteria

rigid (chitin/glucans)

mucopeptide

4

fungi contain ... instead of cholesterol (mammalian) in cell membranes. basis of selective action or ... and ...

ergosterol

polyenes

azoles

5

fungal infections occur in .... ... tissues and they're difficult to treat since antifungals are poorly soluble

poorly vascularized (skin, nails, hair)

6

fungi cause a cellular ... ... leading to a ... ... which may interfere with drug penetration

immune response (antigens/polysaccharides)

granulomatous rxn

7

in general,
short term, low toxicity therapy for ...

long term thus higher toxicity for ...

bacteria

fungi

8

Griseofulvin MOA

microtubule inhibitor

9

Griseofulvin: -static or
-cidal

-static but can be cidal at high doses

10

griseofulvin is best taken with a ... ...

fatty meal (poor orally otherwise)

11

T/F flucytosine is a prodrug

true

12

Amphotericin B MOA

binding to ergosterol (makes pores)

13

Ampho B: cidal or static?

cidal

14

Ampho B is most important for .... infections

systemic

15

Ampho B can increase the uptake of these two drugs:

Ampho B also have synergism with ...

Rifampin

5-FC

Triazoles

16

Ampho B has a wide spectrum which makes in #1 for serious systemic fungal infections BUT it has 4 drawbacks:

IV admin only

not soluble

protein bound

toxicities

17

5-FC is absorbed well orally, soluble, well distributed, not metabolized and has good renal clearance but has the 3 following drawbacks

narrow spectrum
BMD
resistance

18

Azoles- Imidazoles; Triazoles

static or cidal?

static but cidal at high dose

19

Azoles MOA

binds/inhibits heme of lanosterol C14 alpha-demethylase (CYP51)