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Flashcards in Antifungals Deck (29):
1

DOC for superficial mycoses

topical Clotrimazole (Lotrimin)

2

Amphotericin B class

polyenes

(antifungal)

3

Amphotericin B MOA

Binds to ergosterol in fungal cell membrane forming pores; increased permeability --> cell death

4

Gold standard antifungal tx

Amphotericin B (IV)

**broadest spectrum of activity - works against all clinically significant yeasts (candid, histoplasma, aspergillus)

5

Amphotericin B toxicities

"shake and bake"
-infusion-related
-cumulative toxicity (renal damage)


(can pre-medicate with antihistamines, antipyretic, corticosteroids)

6

Azole Antifungals MOA

-inhibit cytochrome P450
-block formation of ergosterol
-slow-killing, considered "static" drugs

7

What is the MC imidazole drug (azole antifungal)?

Clotrimazole (topical only)

8

What is the MC triazole drug (azole antifungal)?

Fluconazole

9

Azole Antifungal ADRs

1) GI upset
2) Hepatitis (LC)

10

Azole Antifungal interactions

1) Drug interactions through the cytochrome P450 system of enzymes
2) increase levels of warfarin

11

What is the MC used systemic antifungal?

Fluconazole

12

Fluconazole is extremely active against ________

C. albicans

13

Echinocandins MOA

cause disruption of the fungal cell wall causing cell death

14

Echinocandins includes which drugs

Caspofungin
Micafungin
Anidulafungin

15

Echinocandins spectrum

Candida, Aspergillus, Pneumocystis

(these drugs are IV only)

16

Echinocandins s/e

mild GI and flushing

17

What is/are the DOC for superficial mycoses

#1 topical Clostrimazole (Lotrimin)

other commonly used are: topical Nystatin (Mycostatin) and oral Terbinafine (Lamisil)

18

T/F: topical administration is not successful for nails and hair

TRUE

must take oral Rx

19

Clotrimazole (Lotrimin) Class

Antifungal (Azole)

20

Clotrimazole (Lotrimin) indication

superficial mycoses - tinea, yeast vaginitis, oral thrush

21

Clotrimazole (Lotrimin) MOA

binds to ergosterol molecules on fungal cell membrane and causes membrane leakage during cell division

22

Nystatin (Mycostatin) indication

superficial mycoses - tinea; oral, esophageal and vaginal Candida

23

Nystatin (Mycostatin) MOA

binds ergosterol molecules on fungal cell membrane resulting in loss of membrane integrity and death of fungal cell

24

________ is often used as prophylaxis in pt. who are at risk for fungal infx, such as AIDS pt with a low CD4 count and pt. receiving chemotherapy

Nystatin

25

Terbinafine class

antifungal (synthetic allylamine)

26

Terbinafine MOA

interferes with ergosterol biosynthesis

27

Terbinafine indications

used primarily for dermatophyte (nail/skin) infx

28

Terbinafine is given continuously for _______ to treat fingernail infx and _______ to treat toenail infx

6 weeks

12 weeks

29

Terbinafine s/e

MC = abdominal discomfort, diarrhea, nausea, HA

LC = elevated liver enzymes, hepatitis, liver damage, liver failure