antifungals

Question 1

antifungal classes

Answer 1

plolynes, allymanines, azoles, echinocandins, pyrimidine inhibitors,

Question 2

polyene drugs

Answer 2

amphotericin B, Nyastatin

Question 3

pollen drug mechanisms

Answer 3

bind ergosterol, create pore

Question 4

amphotericin B

Answer 4

broad but toxic. Severe cryptomeningitis

Question 5

Nyastatin

Answer 5

mucocutanous candida, topical

Question 6

Alyamines

Answer 6

terbinafine

Question 7

terbinafine MOA

Answer 7

block squalene epoxidase

Question 8

terbinafine use

Answer 8

skin/nail infections (not systemic

Question 9

terbinafine toxic

Answer 9

CYP450!! taste and appetite

Question 10

Azoles MOA

Answer 10

inhibit ergosterol

Question 11

Azoles adverse

Answer 11

CYP450!!

Question 12

fluconazole

Answer 12

candida and crypto

Question 13

voriconazole

Answer 13

first line aspergillus, but vision, hallucination, rash, QT

Question 14

posaconazole

Answer 14

candida, crypto, aspergillus Transplant proph.

Question 15

echinocandin drugs

Answer 15

caspofungin

Question 16

caspofungin

Answer 16

inhibit b gluten, candida/aspergillus. Especially resistant aspergillus,

Question 17

pyrimidine inhibitors

Answer 17

flucocystein

Question 18

flucocystein MOA

Answer 18

block DNA/Protien (resistance easy!! need in combo), C meningitis! (with AB).. toxic to bone marrow

Question 19

what drug is transplant prophylaxis

Answer 19

posaconazole- all the main fungi