Protein Synthesis Inhibitors

Question 1

MOA targets

Answer 1

50s or 30s

Question 2

MOR

Answer 2

efflux, target site modification, drug inhibition

Question 3

all are bacteriostatic except

Answer 3

aminoglycosides (and some macrolides)

Question 4

when used?

Answer 4

BL allergy/resistance, intracellular pathogen, no cell wall, in combo with BL

Question 5

which are 30s

Answer 5

tetracycline, aminoglycosides

Question 6

tetracycline drug

Answer 6

doxyclycine, “the tick drug”

Question 7

doxyclycine MOR

Answer 7

efflux. also altered binding

Question 8

doxyclycineMOA

Answer 8

reversible 30s bind, block tRNA binding. intracellular, well distributed

Question 9

doxyclycine spectrum

Answer 9

gram +, -, spirochetes, chlamydia

Question 10

doxyclycine clinical

Answer 10

acne, URI, STD, tick, community MRSA

Question 11

doxyclycine adverse

Answer 11

yellow teeth, GI, photosensitivity

Question 12

aminoglycosides drug

Answer 12

gentamicin

Question 13

gentamicin MOA

Answer 13

30s irreversible bind, prevent translocation

Question 14

gentamicin MOR

Answer 14

inactivate enzyme. also efflux and binding site mutation

Question 15

gentamicin spectrum

Answer 15

gram - bacilli (PSEUD), can be used in synergy with enterococci

Question 16

gentamicin clinical

Answer 16

serious gram - infection, enterococcus endocarditis

Question 17

gentamicin adverse

Answer 17

EAR?KIDNEY

narrow TI

DRUG MONITOR

Question 18

Macrolides drug

Answer 18

Erythromycin, clarithromucin, azythromycin

Question 19

Erythromycin MOA

Answer 19

50s, block translocation

Question 20

Erythromycin MOR

Answer 20

change target site, also efflux

Question 21

Erythromycin spectrum

Answer 21

gram +, Hflu, chlamydia, mycobacterium.

Question 22

Erythromycin Clinical

Answer 22

URI, community pneumonia, PCN allergy, campylobacter, ATPYICAL pneumonia, pertussis

Question 23

Erythromycin adverse

Answer 23

CYP450 Drugs!! QT elongation

Question 24

Erythromycin usually swapped for

Answer 24

Azythro, less effects

Question 25

Lincosamide drug

Answer 25

clindamycin

Question 26

clindamycin MOA

Answer 26

50 s, block elongation/transpeptidase, inhibit toxin

Question 27

clindamycin MOR

Answer 27

change target site, also others

Question 28

clindamycin spectrum

Answer 28

gram +/- anaerobes, gram + aerobes

Question 29

clindamycin clinical

Answer 29

TSS, anaerobic strep/staph, gram + pen allergy

Question 30

clindamycin adverse

Answer 30

Cdif

Question 31

Oxaxolidinone drug

Answer 31

linezolid

Question 32

linezolid MOA

Answer 32

50s, no initiation

Question 33

linezolid MOR

Answer 33

rate

Question 34

linezolid spectrum

Answer 34

gram + cocci (resistant)

Question 35

linezolid clincal

Answer 35

resistant gram -

Question 36

linezolid adverse

Answer 36

thrombocytopenia, serotonin syndrome, peripheral neuropathy