Antifungals Quiz Flashcards
Match the name of the drug class with the name of a medication in that drug class.
Drug Class: Polyene Macrolide
A. Terbinafine
B. Fluconazole; voriconazo
C. Caspofungin
D. Amphotericin B
D
Match the name of the drug class with the name of a medication in that drug class.
Drug Class: Azole
A. Terbinafine
B. Fluconazole; voriconazole
C. Caspofungin
D. Amphotericin B
B
Match the name of the drug class with the name of a medication in that drug class.
Drug Class: Echinocandin
A. Terbinafine
B. Fluconazole; voriconazo
C. Caspofungin
D. Amphotericin B
C
Match the name of the drug class with the name of a medication in that drug class.
Drug Class: Allylamine
A. Terbinafine
B. Fluconazole; voriconazo
C. Caspofungin
D. Amphotericin B
A
Match the drug class with its mechanism of action.
Polyene Macrolides
A. Interferes with ergosterol biosynthesis by inhibiting the fungal enzyme squalene epoxidase.
B. Interfere with fungal cell wall synthesis via inhibition of the enzyme beta-glucan.
C. Interferes with ergosterol synthesis by inhibition of fungal cytochrome P450 enzymes.
D. The sterol in human cell membranes is based upon cholesterol, while fungal cell membranes are composed of ergosterol.
D
Match the drug class with its mechanism of action.
Azole
A. Interferes with ergosterol biosynthesis by inhibiting the fungal enzyme squalene epoxidase.
B. Interfere with fungal cell wall synthesis via inhibition of the enzyme beta-glucan.
C. Interferes with ergosterol synthesis by inhibition of fungal cytochrome P450 enzymes.
D. The sterol in human cell membranes is based upon cholesterol, while fungal cell membranes are composed of ergosterol.
C
Match the drug class with its mechanism of action.
Echinocandins
A. Interferes with ergosterol biosynthesis by inhibiting the fungal enzyme squalene epoxidase.
B. Interfere with fungal cell wall synthesis via inhibition of the enzyme beta-glucan.
C. Interferes with ergosterol synthesis by inhibition of fungal cytochrome P450 enzymes.
D. The sterol in human cell membranes is based upon cholesterol, while fungal cell membranes are composed of ergosterol.
B
Match the drug class with its mechanism of action.
Allylamine
A. Interferes with ergosterol biosynthesis by inhibiting the fungal enzyme squalene epoxidase.
B. Interfere with fungal cell wall synthesis via inhibition of the enzyme beta-glucan.
C. Interferes with ergosterol synthesis by inhibition of fungal cytochrome P450 enzymes.
D. The sterol in human cell membranes is based upon cholesterol, while fungal cell membranes are composed of ergosterol.
A
Match the medication with the correct statement.
Amphotericin B
A. Was originally developed during a search for a new antineoplastic drug.
B. Is nearly insoluble in water and is prepared as either a colloidal suspension or IV.
C. Are classified by the number of nitrogen atoms in a five member ring structure.
D. This class of medications is used only as an IV. They have only minor toxicities.
B
Match the medication with the correct statement.
Flucytosine
A. Was originally developed during a search for a new antineoplastic drug.
B. Is nearly insoluble in water and is prepared as either a colloidal suspension or IV.
C. Are classified by the number of nitrogen atoms in a five member ring structure.
D. This class of medications is used only as an IV. They have only minor toxicities.
A
Match the medication with the correct statement.
Azoles
A. Was originally developed during a search for a new antineoplastic drug.
B. Is nearly insoluble in water and is prepared as either a colloidal suspension or IV.
C. Are classified by the number of nitrogen atoms in a five member ring structure.
D. This class of medications is used only as an IV. They have only minor toxicities.
C
Match the medication with the correct statement.
Echinocandins
A. Was originally developed during a search for a new antineoplastic drug.
B. Is nearly insoluble in water and is prepared as either a colloidal suspension or IV.
C. Are classified by the number of nitrogen atoms in a five member ring structure.
D. This class of medications is used only as an IV. They have only minor toxicities.
D
A young male visits your clinic complaining of severe itching and discomfort. He has a rash in the groin. The symptoms are preventing him from going out in public. You decide:
A. He has community acquired pneumonia and start him on azithromycin because he is allergic to penicillin.
B. He has Tinea Cruris. You admit him for 2 weeks treatment with an IV infusion of a lipid-based amphotericin preparation.
C. He has Tinea Cruris. You advise him to use an OTC topical product- Lamisil AT. (Terbinafine) You advise him to apply the cream twice a day and to continue for at least one week after the rash clears up.
D. You decide he has Tinea Cruris and prescribe anindulafungin because it is new and you want to gain clinical experience with the medication.
C
Ketoconazole has the unenviable association with multiple drug interactions because of its inhibition of cytochromes P450 involved in drug metabolism.
List at least 4 drugs that are metabolized by enzymes inhibited by ketoconazole.List at least 4 other drugs that inhibit hepatic cytochromes P450.
A sample of commonly used drugs with cytochrome P450-mediated metabolism inhibited by ketoconazole (and to a much lesser extent by other azoles) includes chlordiazepoxide, cyclosporine, didanosine, fluoxetine, loratadine, lovastatin, methadone, nifedipine, phenytoin, quinidine, tacrolimus, theophylline, verapamil, warfarin, zidovudine, and zolpidem.
Other drugs that inhibit hepatic cytochromes P450 include chloramphenicol, cimetidine, clarithromycin, disulfiram, erythromycin, ethanol, ethinyl estradiol, fluconazole, furanocoumarins (in grapefruit juice), isoniazid, itraconazole, MAO inhibitors, phenylbutazone, and secobarbital.
Today’s patient presents with severe headache and double vision for the past 3 weeks. He is 14 years old, temp 101.5, his CSF culture is positive for cryptococcal antigen.Identify the treatment of choice.
A. Ketoconazole with fluconazole
B. Ceftriaxone
C. Liposomal Amphotericin plus flucytosine
D. Azithromycin Z Pack
C
