HIV Quiz

Question 1

Combination therapy with at least 3 drugs from at least two different classes is used to reduce the risk of viral resistance. A safe and effective initial regimen is:

A. Efavirenz (NNRTI) plus emtricitabine (NRTI) plus tenofovir (NRTI)
B. Lamivudine (NRTI) plus emtricitabine (NRTI) plus Zidovudine (AZT)
C. Acyclovir plus gancyclovir plus interferon alpha
D. Amprenavir plus Fosamprenavir with ritonavir boost.

Answer 1

A

Question 2

Your patient is admitted in acute renal failure. He has been stable on an antiretroviral regimen containing tenofovir/ emtricitabine/ efavirenz. (combination of NRTI X2 plus NNRTI) If upon work up the renal failure is considered to be caused by an adverse drug reaction- Which agent is most likely to be the culprit?

A. Emtricitabine
B. Tenofovir
C.Efavirenz
D. Antiretrovirals do not have adverse effects on humans.

Answer 2

B

Question 3

Your patient is admitted in acute renal failure. He has been stable on an antiretroviral regimen containing tenofovir/ emtricitabine/ efavirenz. (combination of NRTI X2 plus NNRTI) After evaluation the renal failure is considered to be caused by an adverse drug reaction- Which is the correct course for short term management?

A. Stop the offending medication and continue the other two medications.
B. Continue the regimen using standard doses. The patients kidneys will become tolerant to the medication.
C.Adjust the dose of the suspect medication and consult with the patient’s HIV provider for further direction.
D. Impose a drug holiday and see if the renal failure and the HIV infection spontaneously resolve.

Answer 3

C

Question 4

Emtricitabine class?

Answer 4

Nucleoside reverse transcriptase inhibitor

Question 5

Tenofovir class?

Answer 5

NucleoTide (T for tenofovir) reverse transcriptase inhibitor

Question 6

Lopinavir/ritonavir class?

Answer 6

Protease inhibitor

Question 7

Efavirenz class?

Answer 7

Non-nucleoside reverse transcriptase inhibitor

Question 8

Enfuvirtide class?

Answer 8

Entry inhibitor

(THINK: you can not ENter)

Question 9

Raltegravir class?

Answer 9

Integrase inhibitor

Question 10

Nucleos(t)ide reverse transcriptase inhibitors MOA

Answer 10

Incorporation of these agents into growing viral DNA causes premature chain termination (adenosine and tyrosine analogs)

Question 11

Protease inhibitors MOA

Answer 11

Prevent processing of viral proteins into functional conformations resulting in immature, noninfectious proteins

Question 12

NNRTIs MOA

Answer 12

Inhibits RNA and DNA dependent DNA polymerase. Does not compete with nucleoside triphosphates.

Question 13

Entry inhibitors MOA

Answer 13

Binds to the viral envelope glycoprotein, preventing the conformational change required for fusion of the viral and host CD4 cells.

Question 14

Integrase inhibitors MOA

Answer 14

Binds to a viral enzyme essential to viral replication, and interferes with incorporation into the chromosome of host CD4 cells.