Antigen

Question 1

Ag-Ab reaction is __

Answer 1

ALWAYS SPECIFIC

Question 2

Any molecular structure capable of antibody production

Answer 2

ANTIGEN

Question 3

No ___ should react with a ___

Answer 3

HEALTHY IMMUNE SYSTEM
NORMAL ANTIGEN

Question 4

Capacity of immune system to react with foreign/non-self

Answer 4

MAJOR HISTOCOMPATIBILITY COMPLEX (MHC)

Question 5

Parts of Antigen:

Answer 5

CARRIER PROTEIN
EPITOPE/DETERMINANT

Question 6

Part of Ag responsible for molecular weight

Answer 6

CARRIER PROTEIN

Question 7

Part of Ag responsible for specificity

Answer 7

EPITOPE/DETERMINANT

Question 8

Part of Ag that interacts with Fab portion of Ab

Answer 8

EPITOPE/DETERMINANT

Question 9

Properties of Antigen:

Answer 9

IA

IMMUNOGENICITY
ANTIGENICITY/SPECIFICITY

Question 10

Ability of substance to induce specific immune response —> ___

Answer 10

IMMUNOGENICITY
FORMATION OF IMMUNE LYMPHOCYTES/ANTIBODIES

Question 11

Antibody producing capability of antigen

Answer 11

IMMUNOGENICITY

Question 12

Factors that Affect Immunogenicity:

Answer 12

FSC

FOREIGNNESS
SIZE
CHEMICAL COMPLEXITY

Question 13

Level/extent of immune response

Answer 13

FOREIGNNESS

Question 14

More ___, more immunogenic

Answer 14

FOREIGN

Question 15

Must be recognized as ___ to elicit immune response

Answer 15

FOREIGN

Question 16

Antigen Types:

Answer 16

AAHH

AUTOANTIGEN
ALLOANTIGEN
HETEROANTIGEN
HETEROPHILE ANTIGEN

Question 17

Self
Derived from host
Do not elicit immune response bc “self”

Answer 17

AUTOANTIGEN

Question 18

When autoantigens elicit immune response

Answer 18

AUTOIMMUNE DISORDER

Question 19

Derived from other individuals
Elicit immune response

Answer 19

ALLOANTIGEN

Question 20

Produced from alloantigenic stimulation
Commonly detected in ___ & ___

Answer 20

ALLOANTIBODIES
ANTIBODY SCREENING
IDENTIFICATION

Question 21

Alloantigens of donors are tested

Answer 21

CROSSMATCHING

Question 22

Derived from other species
Elicit immune response

Answer 22

HETEROANTIGENS

Question 23

Heteroantigens that exist in unrelated plants/animals
Either ___ / ___ in structure

Answer 23

HETEROPHILE ANTIGENS
IDENTICAL
CLOSELY RELATED

Question 24

Graft Types:

Answer 24

AIAH

AUTOGRAFT
ISOGRAFT/SYNGRAFT
ALLOGRAFT
HETEROGRAFT/XENOGRAFT

Question 25

From individual’s own body Ex: ___

Answer 25

AUTOGRAFT SEVERE BURNS

Question 26

From identical individuals Ex: ___

Answer 26

ISOGRAFT/SYNGRAFT TWINS

Question 27

From non-identical individuals of same species Ex: ___

Answer 27

ALLOGRAFT KIDNEY, BLOOD TRANSFUSION

Question 28

From other species

Answer 28

HETEROGRAFT/XENOGRAFT

Question 29

SIZE ____ molecule, more immunogenic

Answer 29

LARGER

Question 30

Number of epitope ___ with size of molecule

Answer 30

INCREASING PROPORTIONALLY

Question 31

Albumin Molecular size

Answer 31

30,000-60,000 DALTONS

Question 32

Hemocyanin Molecular size

Answer 32

100,000-MILLION DALTONS

Question 33

Stable, found in vaccine

Answer 33

ALBUMIN

Question 34

Highly complex

Answer 34

HEMOCYANIN

Question 35

___ complex, ___ molecular size

Answer 35

MORE GREATER

Question 36

Molecular size to be Immunogenic

Answer 36

>10,000 DALTONS

Question 37

<10,000 daltons Do not elicit immune response

Answer 37

HAPTEN

Question 38

Overall chemical structure of antigen

Answer 38

CHEMICAL COMPLEXITY

Question 39

Best & strongest Peptide linkages = highly stable —> ___ —> higher chance immune cells will recognize

Answer 39

PROTEIN LONGER CIRCULATION LIFE

Question 40

Examples of Polysaccharides

Answer 40

ENDOTOXIN, PNEUMOCOCCAL CAPSULE

Question 41

Surface antigens Ex: ___

Answer 41

GLYCOPROTEINS ABO, Rh ANTIGENS

Question 42

Example of Polypeptide

Answer 42

INSULIN

Question 43

Least immunogenic bc ___ --> shorter circulation life

Answer 43

NUCLEIC ACIDS, LIPIDS, AMINO ACIDS EASILY DISSOCIATE/DISINTEGRATE

Question 44

Ability of antigen to react specifically with the Ab/cell that caused it to be produced

Answer 44

ANTIGENICITY/SPECIFICITY

Question 45

Incomplete antigen Not immunogenic by itself, needs ___

Answer 45

HAPTEN CARRIER PROTEIN

Question 46

Most common carrier protein of Hapten in circulation

Answer 46

ALBUMIN

Question 47

Any substance that can induce an immune response

Answer 47

IMMUNOGEN

Question 48

Not all ___ are ___, but all ___ are ___

Answer 48

ANTIGENS IMMUNOGENIC IMMUNOGENS ANTIGENIC

Question 49

Special class of immunogen Causes hypersensitivity reactions

Answer 49

ALLERGEN

Question 50

Exaggerated immune response damaging/harmful to individual

Answer 50

HYPERSENSITIVITY

Question 51

Most fatal High exposure rate --> ___

Answer 51

TYPE 1 / IMMEDIATE HYPERSENSITIVITY REACTION DEATH

Question 52

Examples of Hypersensitivity reactions

Answer 52

ASTHMA ATTACK, SYSTEMIC ANAPHYLAXIS

Question 53

Substances added to immunogen to enhance immune response

Answer 53

ADJUVANTS

Question 54

Actions of Adjuvants:

Answer 54

PIS PROLONGS RETENTION TIME OF IMMUNOGEN INCREASES EFFECTIVE SIZE OF IMMUNOGEN STIMULATES INFLUX OF MACROPHAGES AND/OR LYMPHOCYTES

Question 55

Most immunocompetent WBCs

Answer 55

LYMPHOCYTES

Question 56

Examples of Adjuvants:

Answer 56

LPS (LIPOPOLYSACCHARIDES) CFA (COMPLETE FREUNDS ADJUVANTS) ALUMINUM ADJUVANTS

Question 57

Water in oil emulsion of Mycobacterium butericum / Bordatella pertussis

Answer 57

CFA (COMPLETE FREUNDS ADJUVANTS)

Question 58

Most commonly used in clinical setting

Answer 58

ALUMINUM ADJUVANTS

Question 59

Similarity of Affinity & Avidity

Answer 59

BOTH PERTAIN TO STRENGTH OF INTERACTION

Question 60

Strength of interaction between epitope and antigen combining site of antibody

Answer 60

AFFINITY

Question 61

Strength of interaction between complex antigens and antibodies

Answer 61

AVIDITY

Question 62

Difference between Affinity & Avidity

Answer 62

AFFINITY - SIMPLE AVIDITY - COMMPLEX, SUM TOTAL OF INTERACTIONS, MULTIPLE