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Cchm Lec > ANTIGEN > Flashcards

ANTIGEN Flashcards

(72 cards)

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1
Q

They are glycoproteins by nature

A

Immunoglobulin and antibodies

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2
Q

Found in serum portion of blood

A

Glycoproteins

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3
Q

Compositions:
Protein :
Carbohydrate:

A

Protein: 82-96%
Carbohydrates: 2-14%

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4
Q

Behavior of specific methods

A

Serum electrophoresis

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5
Q

Screening test of cc detects clinical disorder

A

Electrophoresis

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6
Q

Different factor of immunoglobulin

A

Cellulose acetate

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7
Q

It has recommended pH alkali

A

Cellulose acetate (pH 8.6)

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8
Q

Differentation of material

A

Citrate agar

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9
Q

Acidic pH are required

A

Citrate agar (pH 6-6.3)

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10
Q

Mnemonics of immunoglobulin

A

G - IgG
A - IgA
M - IgM
E -IgE
D - IgD

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11
Q

Normal serum electrophoresis patterns

A

Albumin
Alpha 1 globulin
Alpha 2 globulin
Beta globulin
Gamma globulin/ gamma region

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12
Q

Immunoglobulin play a role as _________

A

Antigen recognition

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13
Q

Immunoglobulin help in process/biological activity in _______________ and _____________

A

Opsonization and compliment activation

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14
Q

Interaction in specific antigen

A

Antigen recognition

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15
Q

act as Preparation for eating in phagocytosis

A

Opsonization

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16
Q

Compliment system types

A

Antigen dependent: classical pathway
Antigen independent: alternative and lytic pathway

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17
Q

Most abundant proteins

A

Albumin

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18
Q

Slowest protein

A

Gamma region/ gamma globulin

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19
Q

Region where immunoglobulin found

A

Gamma region/ gamma globulin

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20
Q

Effect on beta region

A

Beta gamma bridging

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21
Q

Condition in beta gamma bridging

A

Liver cirrhosis

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22
Q

Tall Spike pattern in gamma region (has elevated plasma protein)

A

Multiple myeloma

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23
Q

Protein found in multiple myeloma

A

Bence jones protein

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24
Q

Full discovery light chain of immunoglobulin in multiple myeloma

A

Bence jones protein

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25
Bence jones protein Temperature: Dissolving temperature:
Temperature: 60 degree celsius Dissolving temperature: 80 degrees Celsius
26
Corresponding proteins: alpha 1 globulin
- Alpha 1 antitrypsin - Alphafetoprotein
27
Corresponding proteins: alpha 2 globulin
- ceuloplasmin - haptoglobin - alpha 2 macroglobulin
28
Corresponding proteins: beta globulin
- hemopoir - transterin - fibrinogen - lipoprotein - protein compliment system
29
Corresponding proteins: gamma region
- antibodies/immunoglobulin
30
Basic 4 chain polypeptide
2 large: heavy or H chain 2 small: light or L chain
31
Chain held together by noncovalent forces
Disulfide linkage/bonds Disulfide interchain bridge
32
Structure of Immunoglobulins was first describe by two scientist.
Gerald Edelman and Rodney Porter
33
Edelman’s work centered on using the__________________ to separate out immunoglobulins on the basis of molecular weight.
analytical ultracentrifuge
34
Immunoglobulin IgG product
Sedimentation coefficient rate
35
IgG has
7s (svedberg unit)
36
What use to unfold IgG
7 molar of urea
37
Used reducing reagent of edelman
2-mercapthoethanol/ mercapthoethanol
38
2 separate fractions in immunoglobulin IgG
3.5s = 50,000 dalton (heavy chain) 2.2s = 22,000 dalton (light chain)
39
Year the won noble prize of edelman and porter
1972
40
FAB mean
Fragment of antigen binding
41
FC mean
Fragment crystallizable
42
scientist discover papain digestion
Rodney porter
43
Papain digestion has ______fragment
3 fragment
44
Cleave of 3 fragment in papain digestion
2 fab (1 light chain; half heavy chain) 1 fc ( 2 half heavy chain)
45
Where can you find na fab
Always in Y
46
Where can you see Fc
Always in the body
47
Scientist discover pepsin digestion
Alfred nisonoff
48
Pepsin digestion has ______ fragment
2 fragment
49
Cleave of 2 fragment in pepsin digestion
1 fab (2 light chain; 2 half heavy chain) 1 fc ( 2 half heavy chain; disintegrated inter small pieces)
50
Structure of immunoglobulin
Variable region Constant
51
Variable region Under: Located:
Under: Fab Located: amino terminal end
52
Constant Under: Located:
Under: FC Located: carbonyl terminal
53
Domains involved by group
IgG, IgA, and IgD = GAD IgM and IgE = ME
54
Domains of IgG, IgA and IgD
Light chain: 2 domains Heavy chain: 4 domains
55
Domains of IgM and IgE
Light chain: 2 domain Heavy chain: 5 domain
56
Light chain discovered in abnormal protein to patient with
Multiple myeloma
57
Kappa Chromosome: Amino acid:
Chromosome: 2 Amino acid: 200
58
Lambda Chromosome: Amino acid:
Chromosome: 22 Amino acid: 220
59
Heavy chain has amino acid
110 amino acid
60
Immunoglobulin classes IgG: IgA: IgM: IgE: IgD:
IgG: gamma chain IgA: alpha chain IgM: Mu chain IgE: epsilon chain IgD: delta chain
61
Antibody variation
Isotype Allotype Idiotype
62
Isotype is under
Heavy chain/ common immunoglobulin
63
Allotype is under
Constant region, immunoglobulin subclasses and kappa
64
Idiotype
Variable region
65
Kappa allotype
IgG = 4 subclasses IgA = 2 subclasses
66
Hinge region composed of
Proline
67
Make flexible of Ig and antigen binding works independently
Proline
68
Basic immunoglobulin structure
Monomer Dimer Polymer
69
Basic immunoglobulin structure and antigen binding site involved
Monomer: 2 antigen binding site Dimer: 4 antigen binding site Polymer: more than 4 antigen binding site
70
Basic immunoglobulin structure according monomer
IgG, IgA (serum IgA/IgA 1), IgM (only found in area of b cell), IgE, IgD
71
Basic immunoglobulin structure according dimer
IgA (secretory IgA/ IgA 2)
72
Basic immunoglobulin structure according polymer/pentameric
IgM (largest)

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