Antihelmintic

Question 0

Drugs active against trematodes

Answer 0

Praziquantel, Bithionol, Metrifonate, Oxamniquine

Question 1

Drugs active against nematodes

Answer 1

Albendazole, DEC, Ivermectin, Mebendazole, Pyrantel pamoate

Question 2

Drugs active against cestodes

Answer 2

Niclosamide, Praziquantel, Albendazole, Mebendazole

Question 3

MOA of Albendazole

Answer 3

Blockage of glucose uptake in both larval and adult parasites
Inhibits microtubule assembly

Also seen in Mebendazole and Thiabendazole

Question 4

Mazzotti reaction

Answer 4

DEC, Ivermectin

Question 5

MOA of Ivermectin

Answer 5

Facilittes GABA-mediated transmission, causing immobilization of parasites

Question 6

MOA of Pyrantel Pamoate

Answer 6

Stimulates nicotinic receptors present at neuromuscular junctions of nematode > contraction > depolarization-induced paralysis

Has no action on fluke and tapeworms
Kills adult nematodes, not eggs

Question 7

MOA of Praziquantel

Answer 7

Increase permeability to calcium

Acts against Trematodes (Schistosoma, Clonorchis sinensis, Paragonimus westermani) and Cestodes

Question 8

Metrifonate

Answer 8

Organophosphate that acts solely against Schistosoma haematobium

Question 9

Oxamniquine

Answer 9

Schistosoma mansoni

Acts on male immature forms and adult schistosomal forms
SE: dizziness

Question 10

MOA of Niclosamide

Answer 10

Uncoupling oxidative phosphorylation or activating ATPases

Acts on Cestodes (with Praziquantel)