Chemotherapy

Question 0

At what phase of cell cycle do Podophyllotoxins act on?

Answer 0

S (DNA synthesis) and G2 (synthesis of components needed for mitosis)

Question 1

At what phase of the cell cycle does Bleomycin act on?

Answer 1

G2 (synthesis of components for mitosis)

Question 2

At what phase of the cell cycle do antimetabolites act on?

Answer 2

S phase (DNA synthesis)

Question 3

What alkylating agent is associated with hemorrhagic cystitis?

Answer 3

Cyclophosphamide (via Acrolein)

Treatment: Mesna (mercaptoethanesulfonate)

Question 4

What are the major side effects of Busulfan?

Answer 4

Adrenal insufficiency, pulmonary fibrosis, and skin pigmentation

Used for CML

Question 5

For which type of CA are Carmustine (BCNU) and Lomustine (CCNU) used?

Answer 5

Brain tumors (highly lipid soluble)

Question 6

At which phase of the cell cycle do antimetabolites act on?

Answer 6

S phase of the cell cycle

Question 7

What is an example of a folic acid antagonist?

Answer 7

Methotrexate

Question 8

What are examples of purine antimetabolites?

Answer 8

Mercaptopurine, Thioguanine

Question 9

What are examples of pyrimidine antimetabolites?

Answer 9

Fluorouracil, Cytarabine, Gemcitabine

Question 10

Antidote for toxic effect of Methrotrexate

Answer 10

Leucovorin (Folinic acid)

Question 11

Which pyrimidine analogue is the most specific for the S phase of the cell cycle?

Answer 11

Cytarabine

Question 12

MOA of Vinblastine and Vincristine

Answer 12

Block the formation of mitotic spindle by preventing the assembly of tubulin dimers into microtubules

Question 13

At which phase of the cell cycle do Vinblastine and Vincristine act on?

Answer 13

M phase

Question 14

At which phase of the cell cycle do Etoposide and Teniposide act on?

Answer 14

Late S and early G2 phase

Question 15

What is the mode of action of Etoposide and Teniposide

Answer 15

Increase degradation of DNA, possibly via interaction with topoisomerase II

Question 16

MOA of Paclitaxel and Docetaxel?

Answer 16

Prevent microtubule disassembly into tubulin monomers

Given IV and used in advanced breast and ovarian cancer

Question 17

Chemotherapeutic of choice for acute leukemia

Answer 17

Daunorubicin

Question 18

SE of Doxorubicin

Answer 18

Cardiotoxicity

Question 19

Most common SE of Bleomycin

Answer 19

Pulmonary dysfunction

Question 20

Where is Dactinomycin used?

Answer 20

Melanoma and Wilm’s tumor

Question 21

Most commonly used glucocorticoid in cancer therapy

Answer 21

Prednisone

Question 22

Flutamide acts on which type of cancer?

Answer 22

Prostatic cancer

Question 23

Imatinib is used for which cancers?

Answer 23

CML and GIST

Question 24

What growth factor inhibitor is used in HER-2/neu positive breast cancer patients?

Answer 24

Trastuzumab

Question 25

What drug is used for palliative treatment of advanced pancreatic cancer?

Answer 25

Gemcitabine

Question 26

Form of recombinant IL-2

Answer 26

Aldesleukin

Question 27

Drugs that can cause nephrotoxicity and ototoxicity

Answer 27

Aminoglycoside | Cisplatin