Antihyperlipidemic Drugs Flashcards
(29 cards)
- lower serum levels of cholesterol
and various lipids - these drugs provide effective
treatment for hyperlipidemia
(increased lipid level in the blood).
ANTIHYPERLIPIDEMIC
DRUGS
ANTIHYPERLIPIDEMIC DRUGS is also called as?
lipid-lowering agents
the most common cause of death among adults (higher in people with hyperlipidemia)
coronary artery disease (CAD)
fatty streaks develop into plaques and
injure the lining of blood vessels is called as?
(atheromas)
give 3 steroid hormones from
glucocorticoid, mineralocorticoid, adrenocorticoid
important source of energy that can be stored all throughout the body
Triglycerides
what is the carrier/ protein capsule that carries fats to transport throughout the body?
Lipoproteins
3 Types of Lipids
cholesterol, tryglycerides, and phospholipids
important in the synthesis of bile acids, steroid hormones, and maintain the integrity of cell membrane
Cholesterol
Four Types of Lipoproteins
- Chylomicrons
- Very Low-Density Lipoproteins (VLDL)
- Low-Density Lipoproteins (LDL)
4.High-Density Lipoproteins (HDL)
what type of lipoprotein is considered as good cholesterol?
High-Density Lipoproteins (HDL)
what type of lipoprotein is considered as bad cholesterol?
Low-Density Lipoproteins (LDL)
Types of Lipoproteins
produced in the GIT from
dietary lipids and deliver energy-rich
triglycerides to the cells throughout the body
Chylomicrons
Types of Lipoproteins
produced in the liver and deliver energy-rich
triglycerides to the cells throughout the body
Very Low-Density Lipoproteins (VLDL)
Types of Lipoproteins
came from transformed VLDL which deliver this
cholesterol TO THE CELLS (for cell membrane
and steroid hormone synthesis) and half are
taken by the LIVER for bile acid production
Low-Density Lipoproteins (LDL)
important in the absorption of
fats (by acting like a dishwashing detergent
that breaks up the grease and fats in the
dishwashing water; bile acids do much the
same thing) and fat-soluble vitamins
bile acids
Types of Lipoproteins
- transport excess cholesterol FROM
CELLS back to the liver
High-Density Lipoproteins (HDL)
ANTIHYPERLIPIDEMIC Drug
- blocks the completion of cholesterol synthesis in the body / statins
- PREGNANCY CATEGORY X
- can be used as prophylaxis for first myocardial infarction attack for patients with multiple risk factors for CAD.
- Older adults are more susceptible to drug toxicity because of underlying conditions that would interfere with metabolism and excretion of drug
HMG-CoA Reductase Inhibitors or
“STATINS”
ANTIHYPERLIPIDEMIC Drug
- exert their effect in the INTESTINE by binding into bile acids which contain a high level of cholesterol.
- used as the treatment for primary
hypercholesterolemia (high cholesterol and high LDL) as an adjunct to diet and exercise. - drug of choice for pregnant women in lowering cholesterol and lipid levels.
Bile Acid Sequestrants
ANTIHYPERLIPIDEMIC Drug
- block the absorption of dietary cholesterol
- one of the new class of drugs approved
(2003) to lower serum cholesterol levels
-Adjunct to diet and exercise as a monotherapy or in combination with HMG-CoA inhibitors or bile acid sequestrants.
Cholesterol Absorption Inhibitors
ANTIHYPERLIPIDEMIC Drug
- It inhibits the release of free fatty acids
from adipose tissue, increases the rate of
triglyceride removal from plasma, and
generally reduces LDL and triglyceride
levels and increases HDL levels. - It inhibits hormone-sensitive lipase that
converts triglycerides to free fatty acids
Nicotinic Acid (Vitamin B3 – Niacin)
Bile Acid Sequestrants drug used to treat pruritus associated with partial biliary obstruction.
Cholestyramine
cole or chole
Bile Acid Sequestrants drug
- drug that increases serum levels of uric acid and may predispose patients to the development of gout
- often combined with bile acid
sequestrants for increased effect.
Nicotinic Acid (Vitamin B3 – Niacin)
