Antihypertenives and diuretics ppt Flashcards Preview

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Flashcards in Antihypertenives and diuretics ppt Deck (20):
1

what converts renin into AT I

angiotensinogen

2

what in the RAAS is a huge player in B/P management and is a huge vasoconstrictor?

AT II

3

ACEi's are used for treatment of what?

htn and CHF

4

what drugs are one of the biggest mediators for intraoperative hypotension

ACEi's

and ARBS

5

ACEi's MOA

Inhibits ACE peptidyl dipetase

this directly interferes with the conversion of ATI to ATII

 

6

what is apowerful vasopressor that also stimulates the release of norepinephrine and aldosterone

ATII

7

what causes the cough associated with ACEi's

the breakdown of bradykinins

8

Frequent SE of ACEi's

Cough

hypotension

Rash

ARF

Angioedema

Increased fetal mortality rate

9

Angiotensin receptor blockers (ARBs) MOA

blocks the angiotensin receptor

interferes with binding of ATII receptor, preventing the formation of ATII

 

 

10

what drugs are ARBs

"sartins"

11

what is the main difference b/t ACEi's and ARBs

ARBs do  ot have the kinase mediated cough

12

what is an example of an osmotic diuretic

Mannitol

13

basic way mannitol (osmotic diuretics work)

increases osmotic gradient and prevents fluid reabsorption

(pulls in more fluids)

14

Are thiazide diuretics K+ sparing?

Nope

15

thiazide diuretic increase the excretion of what

Na+ and K+

16

*************

thiazide diuretics effect where in the kidney to interfere with the normal electrolyte reabsorption

distal renal tubular

17

************

where do diuretic work

Carbonic anhydrase inhibitors

Osmotic diuretcs

loop diuretics

Thiazide diuretics

K+ sparing diuretics

Carbonic anhydrase inhibitors- Proximal convoluted tubule

Osmotic diuretcs- proximal convoluted tubule

loop diuretics- ascending loop

Thiazide diuretics- distal convoluted tubule

K+ sparing diuretics- cortical collecting ducts

18

********

Loop diuretics

ex

action

where they work

lasix

inhibit reabsorption of Na+ and Cl-

ascending loop of henle

19

what is different about bumex from lasix since both loop diuretics

bumex works in both ascending and descending loop

20

done!!

yeah