Vasodilators Flashcards Preview

Anesthesia Pharm II > Vasodilators > Flashcards

Flashcards in Vasodilators Deck (30):
1

Nipride MOA

Decreases Preload, Afterload and Peripheral vascular resistance by metabolism to Nitric Oxide

2

Nipride Dose

Starting Dose: 0.5 mcg/kg/min
Rarely exceeds 3 mcg /kg/min
Max 10 mcg/kg/min for no more then 10-15 min

3

Nipride

May Increase Dead Space R/T decrease pulmonary artery pressure

4

Nipride

Mixed in D5
Protected from light R/T decomposition
Always use a pump and have an A line

5

Nipride Duration

1-3 min after drug termination

6

Nipride Uses

Emergent BP control
Hypotensive techniques
Treatment of pulmonary edema

7

Nipride Onset

Seconds

8

Nipride can cause??

Cyanide Toxicity: Tachyphylaxis
Methemoglobinemia
Increased ICP
Metabolic Acidosis

9

Cyanide Toxicity Treatment?

3% Sodium Nitrate-- 5 mg/kg over 5 min
Methylene Blue 1-2 mg/kg of 1% solution over 5 min (SPO2 will not work while administering)
Sodium Thiosulfate 150 mg/ kg over 15 min

10

Nitroglycerine use to treat?

Angina, HTN, MI ischemia,

11

Nitroglycerine MOA?

Relaxes vascular smooth muscle with venous pooling

12

Nitroglycerine metabolized to?

NO (Nitric Oxide) a potent vasodilator

13

Nitroglycerine cardiac effects

Decreases Preload
Decreases L end-diastolic pressure
Decreases myocardial O2 demand
Increases endocardial perfusion

14

Nitroglycerine other effects

Relaxes bronchial smooth muscle, uterine relaxation, and relaxation of the sphincter of oddi

15

Nitroglycerine special concerns

Glass bottle, special tubing and can cause headaches.
Not as potent as Nipride

16

Nitroglycerine Dose

0.5-10 mcg/kg/min
Small boluses of 50 mcg if BP is high
SL dose 0.4 mg peaks in 4 min

17

Hydralazine MOA

Actually unknown it may work on Nitric Oxide or K+ Channels causing arterial smooth muscle relaxation

18

Hydralazine Side Effects

Tachycardia (good choice for hypertensive bradycardic Pts

19

Hydralazine Dose

5-20 mg

20

Hydralazine Onset

up to 15 min

21

Hydralazine Duration

2-4 hours

22

Hydralazine

Used in Pregnancy Induce HTN

23

Mixing Hydralazine

20 mg per cc. mix with 3 cc NS in a 5 cc syringe. Each cc = 5 mg

24

Adenosine

Potent vasodilator effecting the afterload

25

Adenosine

Used for controlled hypotension at a dose of 60-120 mcg/kg/min

26

Adenosine is approved by the FDA for_____ only

SVT

27

Adenosine SVT dosing

1st dose 6mg
2nd Dose 12 mg
NO 3rd dose anymore

28

Adenosine can cause

Coronary steal in CAD

29

Adenosine is competitively antagonized by?

Aminophylline

30

Choosing an Antihypertensive consider

Preload
Afterload
Contractility
HR
Heart Rhythm
BP ( specifically MAP)