Antihypertensive 🔥🔥

Question 1

What is antihypertensives

Answer 1

Are drugs given when BP is 160/110mm of Hg to protect mother from cerebral hemorrhage, cardiac failure, placenta abruption

Question 2

What is the first line therapy of antihypertensive

Answer 2

Methyldopa
Nifedipine(2nd)

Question 3

What is the mode of action of antihypertensives

Answer 3

Change in myometrial cell membranepermeability
|
or alteration of the membrane band calcium
|
then they synthesize myometrium to produce uterine contractions

Question 4

State the indication of anti hypertensive

Answer 4

1.Induction of abortion
2.Induction of labor
3.acceleration of labor management of 4.atonic postpartum hemorrhage
5.Termination of molar pregnancy
6.Management of ectopic tubal pregnancy

Question 5

State the contraindication of antihypertensive

Answer 5

1.Hypersensitivity to drugs
2.uterus scar
3.pelvic inflammatory disease
4.hepatic and renal disorder

Question 6

State the side effects of antihypertensive

Answer 6

1. Reproductive system: uterine rupture
2. Vascular disorder: hypertension
3. Pregnancy puerperium and perinatal conditions: amniotic fluid embolism

Question 7

State eight antihypertensive drugs

Answer 7

1. Methyldopa
   2.Labetalol
   3.Nifedipine
   4.prazocin
   5.propranol
   6.sodium Nitroprusside
   7.diuretics

Question 8

State the mode of methyldopa

Answer 8

Stimulate Central 𝛂-adrenergic receptors
|
Resulting in decrease of arterial pressure

Question 9

State the dose of methyldopa

Answer 9

Orally- 250mg - 500mg
IV -250mg - 500mg

Question 10

State the indication for antihypertensive

Answer 10

1.Hypertension
2. Gestational hypertension (PIH)
3. Preeclampsia

Question 11

State the side effects of antihypertensive drugs on the mother

Answer 11

Postural hypertension
hemolytic anemia
Sodium retention

Question 12

State the side effects of antihypertensive drugs on the fetus

Answer 12

Intestinal illeus

Question 13

State the contraindication for antihypertensive drugs

Answer 13

Hepatic disorders
Psychic patients
CCF

Question 14

State the mode of action of labetalol

Answer 14

Decrease in systematic arterial blood pressure and systemic vascular resistance
|
because of its combine 𝛂-β-adrenergic blocking activity

Question 15

State the indication for labetalol

Answer 15

Hypertension
Severe hypertension
Hypertensive emergencies

Question 16

Side effects of labetalol on the mother and fetal

Answer 16

Postural hypotension
sodium retention
intestinal ilieus

Question 17

State the contraindication for labetalol

Answer 17

Hepatic disorders

Question 18

State the dosage for labetalol

Answer 18

Orally:100mg t.i.d.
IV: 1-2mg/min until desired results

Question 19

What is propanol (1NN)

Answer 19

Is a sympatholytic non- selective beta blocker

Question 20

State the mode of action of propanol

Answer 20

A non selective better blocker that reduces cardiac oxygen demand
|
by blocking catecholamine-induced increases in heart rate blood pressure and force of myocardial contraction

Question 21

State the dosage of propranol

Answer 21

Orally 80 to 240 mg

Question 22

What is the indication for propranol

Answer 22

Hypertension

Question 23

State the side effects of propranol on the maternal

Answer 23

Severe hypotension
Sodium retention
Bradycardia
Bronchospasm
Cardiac failure
Hypoglycemia

Question 24

State the side effects of propranol on the fetal

Answer 24

Bradycardia
Impaired fetal response to hypoxia
IUGR(intrauterine growth restriction) when began a first and second trimester
Neonatal hypoglycemia
bronchial asthma
Renal insufficiency
diabetes

Question 25

Contraindications for propranol

Answer 25

Bronchial asthma Cardiogenic shock

Question 26

What is prazosin

Answer 26

It is a sympatholytic drug used to treat high blood pressure

Question 27

State the dosage of prazosin

Answer 27

Orally: 1 mg b.i.d

Question 28

What is the indication for prazosin

Answer 28

Hypertension

Question 29

State the side effects prazosin

Answer 29

Hypotension Nasal congestion Fluid retention

Question 30

State the contraindication of prazosin

Answer 30

Hypotension Syncope

Question 31

What is nifedipine

Answer 31

It is a diehydro pyridine calcium Channel blocker

Question 32

State the mode of action of nifedipine

Answer 32

Calcium Channel blockers (Nifedipine) | Block the entry of calcium ions from ECF to ICF | Reduces the contractilty of muscles

Question 33

State the dose of nifedipine

Answer 33

Orally 5 to 10 mg

Question 34

State the indication for nifedipine

Answer 34

Pre term labor Hypertension Chronic or stable angina

Question 35

State the side effects of nifedipine

Answer 35

Flushing Hypotension Headache Tachycardia Inhibition of labor Bradycardia Ankle edema Constipation Placenta ischemia heart block

Question 36

State the contraindications of nifedipine

Answer 36

It could be hazardous due to his synergic effects Bradycardia Cardiogenic shock Systolic pressure<90mmhg Sick sinus syndrome Left ventricle dysfunction

Question 37

What is sodium Nitroprusside

Answer 37

It is a potent vasodilator

Question 38

What are the preparations or types of sodium Nitroprusside

Answer 38

Nipride Nitopress

Question 39

State the mechanism of action of sodium Nitroprusside

Answer 39

Directly relaxes arteriolar venous smooth muscles | Resulting in reduction of cardiac preload and afterload

Question 40

State the indication for sodium Nitroprusside

Answer 40

Hypertensive crisis To reduce bleeding by creating hypotension during pregnancy

Question 41

State the contraindications of sodium Nitroprusside on maternal

Answer 41

Nausea Vomiting Severe hypotension restlessness Decrease reflexes Loss of consciousness