Ergot Derivatives🥶🥶

Question 1

What is ergot derivatives?

Answer 1

Also called ergot alkaloids. Are group of compounds originally isolated from ergot fungus, claviceps purpurea.
Out of the many ergot derivatives, just two are used as oxytocics.

Question 2

State the oxytocic ergot derivatives

Answer 2

Ergometrine
Methylergometrine[ methergin]

Question 3

State the mode of action of ergot derivatives

Answer 3

Acts on the directly on myometrium and excite uterine contractions

Question 4

Types/preparations of ergot derivatives

Answer 4

1. Ergometrine
   0.25mg and 0.5mg ampoules
2. Methergin
   0.2mg and 0.5-1 mg tablet

Question 5

State the indications for ergot derivatives

Answer 5

1. Therapeutic
2. Prophylactic

Question 6

Therapeutically ergot derivatives is used to

Answer 6

1. Stop the atonic uterine bleeding
2. Following delivery, abortion
3. Expulsion of hydatidiform mole

Question 7

Prophylactically ergot derivatives is used in

Answer 7

1. Excessive haemorrhage following delivery
2. Active management 3rd stage of labor

Question 8

Contraindications of ergot derivatives

Answer 8

1. Suspected plural pregnancy
2. Organic cardiac disease
3. Severe eclampsia and pre eclampsia
4. Heart disease and HTN( hypertension)

Question 9

State the side effects of ergot derivatives

Answer 9

1. Nausea and vomiting
2. Rise in blood pressure
3. Stroke
4. Gangrene of toe [rare]