Antihypertensive Drugs Flashcards Preview

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Flashcards in Antihypertensive Drugs Deck (10):
1

Diuretics: Loop

Block transporter in loop of Henle = increase in Na excretion (water goes with it)

2

Agents that affect the CNS:

Centrally Acting (effect and adverse)

Decrease SNS outflow, act at BP control center to reduce SNS activity, reduce BP

Adverse effects: Sedation

3

Vasodilators
(2 types)

1. Ca channel blockers
i. Nifedipine: acts on blood vessels only
ii. Diltiazem and verapamil: act on heart and blood vessels
2. Other direct vasodilators: various mechanisms

4

Agents that act on the Renin Angiotensin System:

ACE inhibitors

Inhibit formation of AII – get decreased BP (from decrease AII get vasodilation, decreased aldosterone - which decreases Na and H2O)

Adverse effects: Teratogenic - cause fetal malformations

5

Diuretics: Thiazide

Block NaCl transporter in distal tubule = increase NaCl excretion

Deplete Na stores = decrease stiffness of VSM

6

Diuretics: K-sparing

Block Na/K transporter = more Na in lumen, more K in body (dont lose K)

Deplete Na stores = decrease stiffness of VSM

7

Agents that act on the Renin Angiotensin System:

All Antagonists

Block receptors for AII/VSM/or decrease aldosterone
Causes vasodilation, decreased BP, decrease in Na and H2O retention

8

Agents that affect the CNS:

Beta-blockers

Decrease HR and FVC initially (reduces CO and BP)
Decrease renin release later (decrease renin, decrease AI and AII, get vasodilation and decrease in aldosterone - less Na and H2O retention) - decrease BP

9

Agents that affect the CNS:

Alpha-blockers (action and adverse effect)

Block receptors on VSM = vasodilation and reduced BP

Adverse effects: orthostatic hypotension (fainting)

10

What happens if you decrease Na stores?

You decrease the stiffness of the VSM