Antihypertensives Flashcards Preview

Sketchy Pharm-Cardio > Antihypertensives > Flashcards

Flashcards in Antihypertensives Deck (21):
1

What type of calcium channels do CCBs attach to?

L type calcium channels

2

Dihydropyridines block L type channels on what cells?

Smooth muscle cells

3

Non-dihydropyridines block L type channels on what cells?

Cardiac muscle cells

4

What are the two types of CCBs?

DHP
NDHP

5

DHP MOA?

DHPs block L type receptors on smooth muscle cells causing vasodilation

6

DHPs have what name?

-dipine

7

NDHP MOA?

NDHPs block L type calcium channels on cardiac muscle cells resulting in decreased contractility

8

NDHPs have what name?

Verapamil
Diltiazem

9

What nodes do NDHPs exert their effects on?

AV and SA

Decreased HR

10

CCBs treat?

Hypertension
Hypertensive emergency
Stable angina
Prinzmetal angina

11

What CCB treats hypertensive emergency in pregnancy?

Nifedipine

12

DHP effects on afterload?

DHPs dilate coronary arteries resulting in decreased afterload

13

DHP adverse effects?

Light headedness
Headache
Peripheral edema
Reflex tachycardia

14

NDHP contraindications?

Patients with heart block
Beta-blockers

15

Primary HTN treatment?

Hydrochlorothiazide
CCB
ACE-I

16

HTN emergency treatment?

Beta-1 antagonists
Labetalol
CCBs
Hydralazine
Nitrate
Nitroprusside
Fenoldopam

17

Labetalol MOA

Beta and Alpha antagonist

18

Hydralazine treatment issue?

Induce reflex tachycardia and worsen angina so administer with beta-blocker to reduce SNS response

19

Nitroprusside MOA

Production of NO causes increased cGMP, relaxing smooth muscle, and causing vasodilation

20

Nitroprusside adverse

cyanide poisoning

21

Fenoldopam MOA

D1 agonist causing increased cAMP resulting in arterial dilation