Heart Failure Medications Flashcards Preview

Sketchy Pharm-Cardio > Heart Failure Medications > Flashcards

Flashcards in Heart Failure Medications Deck (23):
1

Digoxin MOA

Inhibits Na/K+ ATPase. Prevents outward current of Na+. Na+/Ca+ exchanger works instead resulting in an influx of Ca+ and increased cardiac contractility

2

Digoxin "accessory" MOA

Direct vagal stimulation. Acts as an anti-arrhythmic agent

3

Does Digoxin cause hyper or hypokalemia?

Hyperkalemia

4

Digoxin adverse effects

Arrhythmia's
Concave ST segments
Bradycardia (via vegas)
Heart block (AV node)
GI issues
Visual disturbances

5

Digoxin toxicity antidote?

Fab

6

What does digoxin treat?

Chronic systolic heart failure

7

What does Milrinone and Nesiritide treat?

Acute heart failure

8

Milrinone MOA

Inhibition of phosphodiesterase, increased cAMP, and increased cardiac contractility. `

9

Milrinone effect on the heart?

Arteriolar dilation and decreased afterload

10

Nesiritide MOA

Synthetic BNP that increases cGMP.

11

Nesiritide effect on the heart?

Arteriolar and venous dilation resulting in reduced afterload and preload.

12

Explain renin

Renin is synthesized, stored, and released by the JGA. It converts angiotensinogen to angiotensin 1.

13

Explain ACE

ACE is located in vascular endothelium of the lungs. ACE converts angiotensinogen I to angiotensinogen II

14

Effects of Angiotensinogen II

Vasoconstriction
Increased GFR by constricting the efferent arteriole.
Increased sodium/bicarbonate reabsorption at the PCT.
Causes release of aldosterone.

15

Effects of Aldosterone

Increased Na+ and H2O retention.
Increased K+ excretion

16

ACE-Inhibitors names?

All end in -pril

17

ACE-Inhibitors MOA

Prevents the conversion of Ang-I to Ang-II.
Overall decreased pressor effects of Ang-II

18

Do ACE-Inhibitors increase or decrease Creatinine?

Increase

19

ACE-I adverse effects?

Hypotension
Hyperkalemia
Dry cough
Teratogenic

20

ACE-I are used to treat?

Heart failure
Decreased cardiac remodeling
MI
Hypertension
Slow progression of diabetic neuropathy

21

ACE-I contraindication

Hereditary angioedema
NSAID use
Bilateral renal stenosis

22

ARB MOA

ARBs block the angiotensin receptors

23

Aliskiren MOA

Direct renin inhibitor