Flashcards in Heart Failure Medications Deck (23):
Inhibits Na/K+ ATPase. Prevents outward current of Na+. Na+/Ca+ exchanger works instead resulting in an influx of Ca+ and increased cardiac contractility
Digoxin "accessory" MOA
Direct vagal stimulation. Acts as an anti-arrhythmic agent
Does Digoxin cause hyper or hypokalemia?
Digoxin adverse effects
Concave ST segments
Bradycardia (via vegas)
Heart block (AV node)
Digoxin toxicity antidote?
What does digoxin treat?
Chronic systolic heart failure
What does Milrinone and Nesiritide treat?
Acute heart failure
Inhibition of phosphodiesterase, increased cAMP, and increased cardiac contractility. `
Milrinone effect on the heart?
Arteriolar dilation and decreased afterload
Synthetic BNP that increases cGMP.
Nesiritide effect on the heart?
Arteriolar and venous dilation resulting in reduced afterload and preload.
Renin is synthesized, stored, and released by the JGA. It converts angiotensinogen to angiotensin 1.
ACE is located in vascular endothelium of the lungs. ACE converts angiotensinogen I to angiotensinogen II
Effects of Angiotensinogen II
Increased GFR by constricting the efferent arteriole.
Increased sodium/bicarbonate reabsorption at the PCT.
Causes release of aldosterone.
Effects of Aldosterone
Increased Na+ and H2O retention.
Increased K+ excretion
All end in -pril
Prevents the conversion of Ang-I to Ang-II.
Overall decreased pressor effects of Ang-II
Do ACE-Inhibitors increase or decrease Creatinine?
ACE-I adverse effects?
ACE-I are used to treat?
Decreased cardiac remodeling
Slow progression of diabetic neuropathy
Bilateral renal stenosis
ARBs block the angiotensin receptors