Antiibiotics Affecting Protein Synthesis

Question 1

Tetracyclines

Answer 1

tetracycline (P)
doxycycline (acne and VRE)
minocycline
demeclocycline
drugs end with "-cycline"

Question 2

Spectrum of activity of Tetracyclines

Answer 2

Some gram positive
Some gram negative
some anaerobes
Broad Spectrum

Question 3

MOA of Tetracyclines

Answer 3

Inhibition of protein synthesis
Bacteriostatic
Can be bacteriocidal at higher doses and depending on microorganism

Question 4

Kinetics of Tetracyclines

Answer 4

Variable liver metabolism
Renal excretion
When given PO on empty stomach, 75% absorbed

Question 5

Cautions with Tetracyclines

Answer 5

In children younger than 8 (prevents development of teeth)

Hepatic and Renal patients

Question 6

Contraindications with Tetracyclines

Answer 6

ALlergy to Tetracyclines

Pregnancy F and Lactation (crosses placenta and breast milk)

Question 7

Adverse effects with Tetracyclines

Answer 7

Tooth discoloration
Photosensitivity -wear sunscreen
GI upset
Rash
Ototoxic - usually reversible
Can decrease effects of oral contraceptives
High potential to cause super infections

Question 8

Drug interactions with Tetracyclines

Answer 8

PCN G - Decrease effectiveness; may need to be increased PCN G if on combo
Oral contraceptives
Antacids
Calcium - binds to calcium and then calcium cant do what its supposed to do
Warfarin

Question 9

Education with Tetracyclines

Answer 9

Keep out of reach of children
Take on and empty stomach and not with dair
Write expiration date - decompose and become toxic to kidneys
Take antacids or OTC meds that contain mineral salts at least 2-3 hours after tetracycline
Advise women on the pill to use back up method
Wear sunscreen (photosensitivity
Dont use Tetracycline eye drops with contacts - will damage contacts