Exam 2 Review sheet Flashcards
(207 cards)
Antiepileptics
Hydantoins Succinimides Barbiturates Adjunct Therapy Benzodiazepines
Hydrantoins Prototype
phenytoin (Dilantin)
Other drugs in the same class as phenytoin (Dliantin)
ethotoin
fosphenytoin
mephytoin
Indications for phenytoin (Dilantin)
Treats tonic-chronic (grand-mal) & complete-partial seizures
Mechanism of action of phenytoin (Dilantin)
- enhancement of GABA
- inhibition of glutamate
- prolonging inactiveation period of Na Channels (Slows channels down)
- inactivation of Ca channels
Absorption of phenytoin (Dilantin)
slow with PO and IM
Distribution of phenytoin (Dliantin)
Highly protein bound
T1/2 increases as dose increases
Low dose = 6-24 hours T 1/2
Thera peutic dose = 20-60 hr T 1/2
Metabolism of phenytoin (Dilantin)
Liver
Elimination of phenytoin (Dilantin)
Kidney
Therapeutic level of phenytoin (Dilantin)
10-20 mcg/mL (narrow therapeutic range)
Steady state at 7-10 days
Drug interactions with phenytoin (Dilantin)
CYP450 inducer = increase metabolism of other meds
Adverse effects of phenytoin (Dilantin)
CNS: dizziness, ataxia, blurred vision, slurred speech, tremor, confusion
Nausea
gingival hyperplasia
derm reaction (infiltrate steven johnson syndrome)
Liver damage
CV collapse (IVP slow)
hypotension
Contraindications of phenytoin (Dilantin)
CV: sinus bradycardia, sinoatrial block, 2nd and 3rd degree heart block
DM: Increase blood sugars
PG: class D
co-admin with tube feedings (Increase protein levels)
ETOH use & other drug interactions
Education of phenytoin (Dilantin)
Do not stop suddenly (will cause seizures)
Monitor levels (small change in dose = large change in serum level
must shake thoroughly
Good dental hygiene
take with food
DM: Check blood sugar
May decrease effectiveness of birth control
True or false: Always dilute in NS
True
True or false: Compatible w/ D5W (will cause precipitate)
False: NOT compatible with D5W
True or false: Can increase BS
True
What is the prototype of Succinimides?
ethosuximide (Zarontin)
Indications for ethosuximide (Zarontin)
Treat absence (petite mal seizures)
Mechanism of action of ethosuximide (Zarontin)
Delays influx of Ca ions
1 week to see results
Absorption of ethosuximde (Zarontin)
Only oral admin
Distribution of ethosuximide (Zarontin)
Peak: 3-7 hours
Half life: 30-60 hours
Metabolism of ethosuximide (Zarontin)
Liver
Elimination of ethosuximide (Zarontin)
Kidneys