Antimanic Drugs

Question 1

Antimanic Prototype

Answer 1

Lithium

Question 2

Lithium Indications

Answer 2

Treatment of manic episodes of bipolar,

manic-depressive illness.

Question 3

Lithium Actions

Answer 3

Alters sodium transport in nerve and muscle cells; inhibits the release of norepinephrine and dopamine, but not serotonin, from stimulated neurons; increases the intraneuronal stores of norepinephrine and dopamine slightly; and decreases the intraneuronal content of second messengers.

Question 4

Lithium Route

Answer 4

Oral, Oral extended release

Question 5

Lithium Adverse Effects

Answer 5

Central nervous system problems, including lethargy, slurred speech, muscle weakness, and fine tremor; polyuria, gastric toxicity, with nausea, vomiting, and diarrhea progressing; cardiovascular collapse, coma; adverse effects are related to serum drug levels.