Antipsychotic/Neuroleptic Drugs

Question 1

Typical Antipsychotic Prototype

Answer 1

Chlorpromazine

Question 2

Chlorpromazine Indications

Answer 2

Management of manifestations of psychotic disorders, relief of preoperative restlessness, adjunctive treatment of tetanus, acute intermittent porphyria, severe behavioral problems in children, and control of hiccups, nausea, and vomiting.

Question 3

Chlorpromazine Actions

Answer 3

Blocks postsynaptic dopamine receptors
in the brain, depresses those parts of the brain involved in wakefulness and emesis, anticholinergic, antihistaminic, alpha-adrenergic blocking.

Question 4

Chlorpromazine Route

Answer 4

Oral, IM

Question 5

Chlorpromazine Adverse Effects

Answer 5

Drowsiness, insomnia, vertigo, extrapyramidal symptoms, orthostatic hypotension, photophobia, blurred vision, dry mouth, nausea, vomiting, anorexia, urinary retention, photosensitivity.

Question 6

Atypical Antipsychotic

Answer 6

Clozapine

Question 7

Clozapine Indications

Answer 7

Management of severely ill patients with schizophrenia who are unresponsive to standard drugs; reduction of risk of recurrent suicidal behavior in patients with schizophrenia or schizoaffective disorder.

Question 8

Clozapine Actions

Answer 8

Blocks dopamine and serotonin receptors, depresses the reticular activating system, anticholinergic, antihistaminic, alpha-adrenergic blocking.

Question 9

Clozapine Route

Answer 9

Oral

Question 10

Clozapine Adverse Effects

Answer 10

Drowsiness, sedation, seizures, dizziness, syncope, headache, tachycardia, nausea, vomiting, fever, neuroleptic malignant syndrome.