antimetabolites

Question 1

Methotrexate

Folic acid analog

Answer 1

inhibits dehydrofolate reductase enzyme to prevent tetraydrofolate cofactors to provide carbon groups to DNA and RNA synthesis…prevents synthesis

Question 2

methotrexate toxicity

Answer 2

GI toxicity (mucositis, esophagitis)
Renal precipitation (weak acid, crystallizes)
high dose fatal bone marrow --> leucovorin rescue