cancer therapy drugs

Question 1

What drug treats Chronic Mylogenous Leukemia?

Answer 1

IMATINIB -> a Tyrosine Kinase inhibitor of the fusion genes BCR-ABL

Once a fatal disease, oral medications now keep CML under control for 80% to 90% of patients.

Question 2

What drug treats “Lung primary Adenocarcinoma” caused by EML4-ALK fusion gene …overactive tyrosine kinase

Answer 2

crizotinib

Question 3

What drug treats “Lung primary adenocarcinoma” caused by point mutations in ERBB1 gene?

Answer 3

Erlotinib

which inhibits the constitutively active EGFR TK

Question 4

What drug treats melanoma caused by a BRAF mutation?

Answer 4

Vemurafenib

Question 5

What drug treats HER2 positive breast cancer?

“Tracy” is sick

Answer 5

Trastuzumab…… antibody against the HER2

receptor TK for early stage breast cancers with overexpressed ERBB2 gene.

Question 6

What drug treats colon cancer caused by overactive EGFR?

C for “colon”

Answer 6

Cetuximab antibody drug

*obviously ineffective if the tumor possesses a downstream RAS mutation

Question 7

what drug treats Glioblastoma?

Answer 7

Bevacizumab prevents VEGR activation

Question 8

progressive renal cancer

TK

Answer 8

Sunitinib a TK inhibitor

Question 9

Tamoxifen is used for what kind of cancer?

Answer 9

an antagonist of the estrogen receptor in breast tissue
useless in hormone independent breast cancers
*add Everolimus if metastatic
*tam is used to prevent recurrence as well

Question 10

Enzalutamide

androgen receptor blockade

Answer 10

prostate adenocarcinoma

Castrate resistant: progressing with markedly suppressed testosterone levels

Question 11

Basal cell carcinoma?

Answer 11

Vismodegib

Hedgehog pathway inhibitionn