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PH3101 > Antimicrobial Chemotherapy 4 > Flashcards

Antimicrobial Chemotherapy 4 Flashcards

1
Q

What is the function of Penicillin Binding Proteins (PGP) 2?

A

Transglycoslase and transpeptidase activities
- initiates peptidoglycan insertion at new growth site

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2
Q

Give examples of antibiotics which target PGP 2

A

Mecillinam
Imipenem

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3
Q

What is the function of Penicillin Binding Proteins (PGP) 3?

A

Transglycolase and transpeptidase activities
- formation of the cross-wall at cell division

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4
Q

What is the function of Penicillin Binding Proteins (PGP) 4?

A

DD-carboxypeptidase
- control of peptidoglycan cross-linking
DD-endopeptidase
- hydrolysis of cross-links during elongation

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5
Q

Give examples of antibiotics which target PGP 4

A

Benzylpenicillin
Ampicillin
Imipenem

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6
Q

Give an antibiotic which targets PGP 7

A

Penems

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7
Q

Give examples of antibiotics contra-indicated in penicillin allergy

A

Amoxicillin
Ampicillin
Co-amoxiclav
- Augmentin
Flucloxacillin
Benzylpenicillin
Penicillin V
- phenoxymethylpenicillin
Piperacillin with tazobactam
- Taxocin
Pivmecillinam
Ticarcillin
Ticarcillin with clavulanic acid

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8
Q

Give examples of antibiotics contraindicated in severe penicillin allergy, or cautioned in non-severe penicillin allergy

A

Cefalexin
Cefaclor
Cefixime
Cefotaxime
Ceftazidime
Ceftriaxone
Cefuroxime
Cefuroxime
Imipenem plus cilastatin
Meropenem
Aztreonam
Ertapenem

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9
Q

Which antibiotics should be used in high-risk patients when treating Clostridium difficile?

A

2nd generation cephalosporins
- cefuroxime
- cefaclor
3rd generation cephalosporins
- cefotaxime
- ceftazidime
- ceftriaxone

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10
Q

Which antibiotics should be used in medium-risk patients when treating Clostridium difficile?

A

Co-amoxiclav
Amoxicillin
1st generation cephalosporins
- cefalexin
Carbapenems
- meropenem
- imipenem
- ertapenem

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11
Q

Give two examples of glycopeptide antibiotics

A

Vancomycin
Teicoplanin

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12
Q

What is the indication for vancomycin?

A

Prophylaxis and treatment of endocarditis and other serious infections caused by gram-positive bacteria
- Multi Drug Resistance
Treatment of peritonitis

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13
Q

What is the indication for teicoplanin?

A

Bactericidal against gram-positive aerobes and anaerobes
- Multi Drug Resistance staphylococci

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14
Q

What is the mechanism for teicoplanin?

A

Inhibition of peptidoglycan synthesis by inhibiting transglycosylase which produces linear strands of peptidoglycan
Prevent the transfer and addition of muramyl-pentapeptide building blocks

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15
Q

What is the target for glycopeptides?

A

Recognise the D-Ala-D-Ala bond

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16
Q

What is the mechanism of bacitracin and bacitracin zinc?

A

Blocks the function of the lipid carrier molecule that transfers cell wall subunit across the cell membrane

17
Q

What is the mechanism of D-cycloserine?

A

Compete with D-alanine for incorporation in the cell wall

PH3101 (33 decks)

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