What kind of drugs are nevirapine, delavirdine, and efavirenz?
What are the 2 neuraminidase inhibitors?
Zanamavir and Oseltamivir
What drug can be used to treat HBV, HCV, and Kaposi's?
What CMV drug must be coadministered with probenecid?
Cidofovir due to nephrotoxicity
What is the AE of zidovudine?
This drug inhibits renal dehydropeptidase I to prevent breakdown of imipenem
How do you prophylax against endocarditis from surgery and dental procedures?
Which antibiotic inhibits dihydrofolate reductase? Which drug also does this as an antineoplastic?
What is the major AE of chloroquine?
Which generation of cephalosporins covers gram positive bacteria and Proteus, E. coli, and Klebsiella?
First Generation (PEcK)
Which enzyme activates isoniazid to the active form?
Mycobacterial Catalase Peroxidase (KatG)
How do you prophylax against strep pharyngitis in a kid with Hx of rheumatic fever?
What is the MOA of griseofulvin?
Interferes with fungal microtubules and disrupts mitosis
Which drugs block the conversion of lanosterol to ergosterol?
What are the 3 anti-staphylococcal penicillins?
Nafcillin, Oxacillin, and Dicloxacillin
MOA of oseltamivir
neuraminidase inhibitor that decreases release of influenza A and B viral progeny
What bugs are covered by second generation cephalosporins?
Gram positives, Haemophilus, Enterobacter, Neisseria, Proteus, E. coli, Klebsiella (HEN PEcK)
What drug inhibits HIV integrase
What is the advantage of a cephalosporin over a penicillin regarding beta-lactamase?
Cephalosporins are overall less sensitive to beta lactamase
Which 2 antifungals affect membrane function?
Amphotericin B, Nystatin
Which type of anemia is formed by trimethoprim? What could you give to rescue?
Megaloblastic anemia (lack of folate); rescue with folinic acid (leucovorin) same as for methotrexate
Why are tetracyclines so effective against Chlamydia and Rickettsia?
They can accumulate intracellularly
Describe the full MOA of acyclovir
Gets into cells and is monophosporylated by viral thymidine kinase to the active form. This then functions as a guanosine analog and causes CHAIN TERMINATION (no 3' OH)
In which setting would you choose aztreonam over aminoglycosides? Can you give both?
In renal failure because aminoglycosides are nephrotoxic. However, the two are synergistic so can be given together under other circumstances.
What is famciclovir used for?
VZV; this drug is related to acylclovir
How do you treat tuberculous leprosy?
Dapsone and Rifampin
MOA of ergosterol
Binds ergosterol to form membrane pores in fungi
What other disorders can hydroxychloroquine be used for aside from malaria?
What highly virulent bug is covered by ceftaroline?
Which beta-lactams may cause vitamin K deficiency? How would this manifest?
Cephalosporins, bleeding (loss of II, VII, IX, X, and proteins C and S)