Name 5 Flaviviruses
HCV (only one not an arbovirus), Yellow fever, West Nile, St. Louis encephalitis, and Dengue
What determines tropism when phenotypic mixing of viruses occurs?
The coat that the virus takes with it (this is when 2 viruses infect a cell and one takes the other's coat; HOWEVER, after infection in the new tissue, the virions expressed will have their original coat)
Which picornavirus is not spread via a fecal oral route?
What is Gerstmann-Straussler-Scheinker syndrome?
inherited prion disease
What are the likely organisms for the following neurologic findings in an AIDS pt 1) Encephalopathy 2) Abscess 3) Meningitis 4) Retinitis 5) Dementia
1) JC virus reactivation 2) Toxoplasma gondii 3) Cryptococcus neoformans 4) CMV (with cotton wool spots) 5) directly related to HIV
What is a Tzanck test used to detect? What is it looking for?
Herpes (HSV 1 and 2, and VZV); it is looking for multinucleated giant cells
What is an adult infection with parvovirus like?
Rheumatoid arthritis-like with pure red cell aplasia
What monoclonal antibody is used to prevent pneumonia from RSV infection in premature infants? MOA
Pavalizumab (binds to F protein, fusion protein)
Which RNA viruses do not replicate in the cytoplasm?
Influenza and retroviruses
Which hepatitis is a flavivirus? Which is a picornavirus?
Flavivirus enveloped (+) ssRNA = Hep C; Picornavirus naked (+) ssRNA = Hep A
What type of genome must a virus have in order to do recombination?
Can you give live-attenuated vaccines to HIV patients?
If they are not showing signs of IC then it is at least safe (according to FA) to give them the MMR
What are 3 cancers associated with EBV?
1) Hodgkin's lymphoma 2) Burkitt's lymphoma and 3) Nasopharyngeal carcinoma (Asians)
Name 2 recombinant vaccines
HBV and HPV (6 and 11 = warts; 16 and 18 = cervical CA)
What kind of virus is Lymphocytic Choriomeningitis virus?
LCMV = Arenavirus
Which virus can cause a heterophile antibody negative (sheep abs) infectious mononucleosis?
What is the kissing disease? What is transmitted by the kissing bug?
Epstein-Barr virus; Trypanosoma cruzi
What causes pure red aplasia and rheumatoid arthritis like Sx in adults?
What inclusion body do you commonly see in herpes infections?
Cowdry type A intranuclear (intranuclear because herpes viruses replicate IN THE NUCLEUS!)
What kind of virus is norovirus? Rotavirus?
Norovirus = a calicivirus (SS linear RNA), Rotavirus = a reovirus (DS linear 10-12 segments RNA)
Name 3 togaviruses
Measles (Rubella), Eastern Equine encephalitis; Western Equine encephalitis
What is exanthem subitum?
What are the 5 picornaviruses?
Poliovirus, Echovirus, Rhinovirus, Coxsackievirus, HAV
What 3 enzymes are coded for on pol gene in HIV?
reverse transcriptase, aspartate protease, and integrase
What mutations lead to immunity of AIDS? Which for a slower course?
Homozygous CCR5 mutations; Heterozygous CCR5 mutations
What is viral reassortment?
Occurs when viruses with segmented genomes exchange segments of their genomes (co-infect a cell)
What is viral phenotypic mixing?
When 2 viruses infect a cell and one virus takes the coat of the other virus
What cells are infected by EBV? Receptor?
B cells; CD21
What are the 6 live attenuated vaccines?
Nasal spray influenza, MMR, Yellow fever, Sabin polio, small pox, and chickenpox
Which flavivirus is NOT an arbovirus?