Hypersensitivity, Hemolytic Anemia.
Extended Spectrum Penicillins
Hypersensitivity, Rash, Pseudomembranous colitis
Penicillinase Resistant Penicillins
Hypersensitivity, Methicillin = interstitial nephritis
Penicillin + ß lactamase inhibitor. Sulbactam is another inhibitor.
Cephalosporins: Penicillinase resistant
Cross-reaction with PCN allergy, hypersensitivity, vitamin K deficiency, DDI with warfarin, increases nephrotox of Aminoglycosides, disulfiram-like rxn with EtOH, superinfections
Carbapenems. Beta lactamase resistant.
GI Upset: Nausea, Vomiting, Diarrhea. Skin rash. Seizures possible at high doses. Because significant toxicity use as last resort.
Usually non toxic and well tolerated. Occasional GI upset.
Common: Chills, Fever, Rash, Most Severe: Ototoxic, Nephrotoxic >> Routine Cp monitoring, Thrombophlebitis (NOT)
N/V/D, acute cholestatic hepatitis, eosinophilia, skin rashes, prolonged QT interval. Most severe: CYP450 inhibition (except Az) - increase [theophyllines] + [oral anticoagulants]
Severe diarrhea, fever. Pseudomembranous colitis
Infusion related pain and phlebitis, inhibits CYP3A4, significant DDIs possible
Well tolerated, minor GI, HA, rash, rare thrombocytopenia, weak MAO inhibitor
- N/V/D. Bone & tooth abnormal dvlpmnt, & fungal superinfections,
- cannot be taken w/antacids or milk or iron-containing substances
- & DDI w/metal cations, milk, Fe b/c inhibits absorbtion in gut.
- DDI w/inducers.
Nephrotoxicity esp w/ cephalosporins, Ototoxicity esp w/ loop diuretics, Teratogen = Routine monitoring of Cp (NOT)
Disulfuram-like with EtOH = nausea, HA, metallic taste. No drinking allowed on the train, if you eat the train like king kong, will get metallic taste in mouth
GI upset, Superinfection, HA, Dizziness, rash, tendonitis/rupture.
Contraindicated in pregnancy and children under 12.
Don’t take with antacids.
- Moderately safe, renal damage “crystallura”
- hemolysis if G6Pd (hemolytic anemia)
- kernicterus in infants
- hypersensitivity rxns (fever, rash)
- DDIs with displacement of other compounds from albumin (warfarin),
- GI upset, contraindicated in pregnancy.
- Trimethorpin causes serious marrow issues.
GI upset (A/N/V/D), hypersensitivity (hemolytic anemia), neuropathies.
Antituberculuar Agents (Rifampin)
Red/orange body fluids, anorexia, N/V, diarrhea, rash, hypersensitivity, fever, HA, drowsiness, minor hepatotoxicity/jaundice, DDI by inducing CYP450