Flashcards in Antimycobacterial drugs (3 Q's on the test) Deck (33):
mycobacteria can be identified by what kind of test
acid fast stain (ziehl-neelsen stain) They dont lose their color
first line of therapy for antituberculosis drugs
Rifamycins: -cidal or -static?
inhibition of bacterial RNA polymerase
inhibition of mycolic acid biosynthesis (cell wall)
Isoniazid: -cidal or -static?
-static but can be -cidal with high enough dose
Which of the RIPE drugs are pro-drugs?
Pyrazinamide (activated at low pH)
inhibits mycolic acid biosynthesis (cell wall)
disrupts membrane potential
ribosomal protein binding
Ethambutol: -cidal or -static?
inhibits arabinose polymerization (cell wall)
What drugs are the 2nd line of therapy for antituberculosis drugs?
Para-aminosalicylic acid (PAS)
Aminoglycosides: -cidal or -static
Streptomycin, Amikacin and Kanamycin are all
Aminoglycosides MOA? (streptomycin, amikacin, kanamycin)
protein synthesis inhibition
Fluoroquinolones: -static or -cidal
Ciprofloxacin and Levofloxacin are both
Fluoroquinolones (ciprofloxacin and levofloxacin) MOA?
DNA gyrase, Topo IV inhibition
Capreomycin: -static or -cidal
protein synthesis inhibition (50S and 30S)
Ethionamide: -cidal or -static?
Ethionamide is similar to ... because ...
its a pro-drug and it inhibits mycolic acid biosynthesis (cell wall)
3 drugs that inhibit mycolic acid biosynthesis
Cycloserine: -cidal or -static
prevents D-ala and D-ala-D-ala formation
para-aminosalicylic acid (PAS): -cidal or -static?
folate synthesis inhibitor (like sulfonamides)
T/F: all the RIPE drugs are absorbed well orally
what can toxicity of ethambutol cause?
visual disturbances, can lead to blindness with sudden onset
Ethambutol shows synergism with ....
Rifampins (allows more drug to enter cell by disruption of cell wall)
route of administration for capreomycin?
ATP synthase inhibitor
Aztreonam is good against Gram positive or Gram negative bacteria?