Antimycobacterial drugs (3 Q's on the test) Flashcards Preview

Pharm Exam 4 SP2018 > Antimycobacterial drugs (3 Q's on the test) > Flashcards

Flashcards in Antimycobacterial drugs (3 Q's on the test) Deck (33):
1

mycobacteria can be identified by what kind of test

acid fast stain (ziehl-neelsen stain) They dont lose their color

2

first line of therapy for antituberculosis drugs

RIPE:
Rifamycins
Isoniazid
Pyrazinamide
Ethambutol

3

Rifamycins: -cidal or -static?

-cidal

4

Rifamycin MOA

inhibition of bacterial RNA polymerase

5

Isoniazid MOA

inhibition of mycolic acid biosynthesis (cell wall)

6

Isoniazid: -cidal or -static?

-static but can be -cidal with high enough dose

7

Which of the RIPE drugs are pro-drugs?

Isoniazid
Pyrazinamide (activated at low pH)

8

Pyrazinamide MOA

inhibits mycolic acid biosynthesis (cell wall)
disrupts membrane potential
ribosomal protein binding

9

Ethambutol: -cidal or -static?

-static

10

Ethambutol MOA

inhibits arabinose polymerization (cell wall)

11

What drugs are the 2nd line of therapy for antituberculosis drugs?

Aminoglycosides
Fluoroquinolones
Capreomycin
Ethionamide
Cycloserine
Para-aminosalicylic acid (PAS)

12

Aminoglycosides: -cidal or -static

-cidal

13

Streptomycin, Amikacin and Kanamycin are all

aminoglycosides

14

Aminoglycosides MOA? (streptomycin, amikacin, kanamycin)

protein synthesis inhibition

15

Fluoroquinolones: -static or -cidal

-cidal

16

Ciprofloxacin and Levofloxacin are both

fluoroquinolones

17

Fluoroquinolones (ciprofloxacin and levofloxacin) MOA?

DNA gyrase, Topo IV inhibition

18

Capreomycin: -static or -cidal

-cidal

19

Capreomycin MOA?

protein synthesis inhibition (50S and 30S)

20

Ethionamide: -cidal or -static?

-cidal

21

Ethionamide is similar to ... because ...

Isoniazid (INH)

its a pro-drug and it inhibits mycolic acid biosynthesis (cell wall)

22

3 drugs that inhibit mycolic acid biosynthesis

Isoniazid
Pyrazinamide
Ethionamide

23

Cycloserine: -cidal or -static

-cidal

24

Cycloserine MOA

prevents D-ala and D-ala-D-ala formation

25

para-aminosalicylic acid (PAS): -cidal or -static?

-static

26

PAS MOA?

folate synthesis inhibitor (like sulfonamides)

27

T/F: all the RIPE drugs are absorbed well orally

true

28

what can toxicity of ethambutol cause?

visual disturbances, can lead to blindness with sudden onset

29

Ethambutol shows synergism with ....

Rifampins (allows more drug to enter cell by disruption of cell wall)

30

route of administration for capreomycin?

parenteral only

31

Sirturo MOA?

ATP synthase inhibitor

32

Aztreonam is good against Gram positive or Gram negative bacteria?

Gram negative

33

Which of the following is antagonistic when used with amoxicillin?
vancomycin
amikacin
sulfamethoxypyridazine
moxifloxacin
metronidazole

sulfamethoxypyridazine (because it is static while the other drugs are cidal)