Antineoplastic

Question 1

chemotherapeutic drugs

Answer 1

destroy or injure invading organisms or tissues: antimicrobial, antiparasitic, and antineoplastic drugs

Question 2

antineoplastic drugs may distinguish cancer cells from normal cells based on:

Answer 2

• rate of growth and porliferation
• consumption of selected nutrients
• consumptoin of o2

Question 3

what normal cells proliferate rapidly and are affected by antineoplastic drugs?

Answer 3

bone marrow - anemia, leukoplakia, infections
hair follicles - alopecia
buccal mucosa - stomatitis
gonads - impotence
embryonic tissue - teratogenicity

Question 4

which types of cancer often have primary resistance to antineoplastic drugs?

Answer 4

malignant melanoma
brain cancer
rencal cell cancer

Question 5

tumor lysis syndrome

Answer 5

side effects caused by debris from dead cancer cells

common with leukemia and lymphoma

Question 6

complications of tumor lysis syndrome

Answer 6

hyperkalemia
hyperphophatemia
hypocalcemia
hyperuricemia
hyperuricosuira

Question 7

what are the 3 methods of antineoplastic classification?

Answer 7

1) cell cycle: m=mitosis, s= DNA synthesis
2) mechanism of action: alkylating agents, antimetablites, microtubule inhibitors
3) chemical classification of antineoplasic: platinum analogues or steroid inhibitors

Question 8

methotrexate MOA, Indications

Answer 8

antineoplastic
inhibits folic acid synthesis
I: lung cancer, breast CA, leukemia, Hodgkins and non-hodgkin lymphoma, cutaneous T cell lymphoma, osteosarcoma
SE: N/V/D, stomatitis, alopecia, myelosuppresion, peripheral neuropathy, heptaotoxicity

Question 9

Doxorubicin MOA, etc

Answer 9

antineoplastic, antibiotic-like, anthracycline: inhibits DNA and protein synthesis
I: efficacious for broadest spectrum, IV rapidly, cardiotoxicity.

Question 10

Cyclophosphamide MOA, etc

Answer 10

antineoplastic, alkylating agent, inhibits DNA replication, transcription of RNA, and nucleic acid function
I: acute lymphocytic leukemia, Hodgkins dz, non-Hodgkins lymphoma, breast, ovaria, lung cancers, mutiple myeloma, sarcomas SE: nausea, vomitting, diarrhea, abd pain

Question 11

Paclitaxel MOA etc

Answer 11

antineoplastic and microtuble inhibitor
reversibly binds to microtubule preventing cell division
IV, Pacific Yew Tree, I: advanced ovarian ca, metastatic breast ca, SE: N/V/ appetite loss, joint pain, alopecia, fever, chlls, sore throat

Question 12

Tamoxifin

Answer 12

antineoplastic hormone inhibitor/estrogen antagonist
binds estrogen receptor and blocks RNA synthesis
I: early breast ca, hot flashes, men sx, increased risk of uterine ca