Antineoplastics Flashcards Preview

FMS Week 6 > Antineoplastics > Flashcards

Flashcards in Antineoplastics Deck (8)
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1
Q

Resistance of imatinib could arise by means of which of the following

BRA/ALB gene amplification

A mutation in ALB tyrosine kinase

Induction of ABC transporter P-170, the product of MDR-1 gene

A

All 3!!!

2
Q

What does -nib mean?

A

Nibs are inhibitors!

3
Q

-tinibs

A

inhibitors of kinases

4
Q

-anibs

A

inhibitor of angiogenesis

5
Q

-rafenibs

A

inhibitors of raf kinase (serine/threonine)

6
Q

Toxicity from checkpoint inhibitors prominently includes

Nephrotoxicity

Hepatotoxicity

Autoimmunity

Vertigo

Insomnia

A

Autoimmunity

7
Q

Most classical antineoplastic agents function by

A

directly or indirectly interefering with nucleic acid synthesis

8
Q

Classical antineoplastics

A

Act relatively nonspecific. This means that you can have a lot of toxicity to any replicating cell population (bone marrow, GI, hair follicles)

Bone marrow suppression most often limiting step

Ulceration of oral and GI mucosa

Alopecia

Impaired wound healing

Crystalluria due to hyperuricemia