Antiparasitics Flashcards Preview

Ther 201 LE 3 > Antiparasitics > Flashcards

Flashcards in Antiparasitics Deck (28):
1

Examples of Protozoa

plasmodium
trichomonas
amoeba
giardia
pneumocystis
toxoplasma

2

Examples of Helminths

tapeworms
flukes
roundworms
pinworms
hookworms

3

Chemotherapy of Amoebiasis

diloxanide fuoranate
paromomycin
metronidazole

4

Chemotherapy of Malaria

chloroquine, primaquine, sulfadoxine+pyrimethamine, quinine, tetracycline, artemether-lumefantrin

5

Chemotherapy of Giardiasis

Metronidazole

6

Amoebiasis etiologic agent

Entamoeba hystolitica

7

common symptom of amoebiasis

bloody stool

8

nonpathogenic Entamoeba and its difference

E. dispar / microscopic.
E. hystolitica ingests RBC

9

Why is amoebiasis both over and underreported?

Under - infected don't seek medical attention
Over - misdiagnosed nonpathogenic cases

10

Types of Amebicides

Mixed
Luminal

11

eradicate intestinal and systemic amoeba

Mixed
eg. Metronidazole

12

eradicate intestinal amoeba ONLY

Luminal
eg. Diloxonide, paramycin

13

Spectrum of Metronidazole

Anaerobes
Gram-negative and Gram-positive bacilli
Gram-positive cocci
Parasites: T. vaginalis, E. histolytica, Giardia lamblia
H. pylori

14

ADME Metronidazole

90-100% BA, wide distribution, 30-60% metabolized in liver to hydroxymetronidazole (60-80% bioactive), t1/2 - 5012 hours, excretoin via urine and feces (20, 6-15%)

15

Metronidazole Indication

anaerobic infections due to Bacteroides fragilis including those involving the CNS
Antibiotic induced pseudomembranous colitis
Bacterial vaginosis
Prophylaxis of anaerobes in colorectal and gyne surgery

16

Metronidazole ADR

Nausea
Headache
dry mouth
metallic taste
pancreatitis
ataxia
encephalopathy
seizures

17

Drug Interactions Metronidazole

Disulfiram-like reaction when given with alcohol

18

Diloxanide furoate ADR

flatulence, dry mouth, urticarial pruritus

19

Causes of Malaria

Plasmodium
P. falciparum (most common)
P. vivax
P. ovale
P. malariae

20

Types of Malarial Drugs

Blood Schizonticide
Tissue Schizonticide

21

T/F Monotherapy is advised in Malaria.

F! Always in combination

22

Blood Schizonticide examples

FQCAM
Fansidar
Quinine
Chloroquine
Artemisinin
Mefloquine

23

Tissue Schizonticide examples

Primaquine

24

not used anymore in Palawan due to reported resistance

Chloroquine

25

reported to have caused psychiatric problem in American soldiers after prophylaxis

Mefloquine

26

First line drugs for Malaria

Artemisining combination drugs

27

Brain available in the Philippines for Malaria

Coartem (Artemether - Lumefantrine)

28

Artemether MOA

inhibition of parasite calcium ATPase