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Behavior > Antipsychotics > Flashcards

Antipsychotics Flashcards

1
Q

MOA of Lithium

A

inhibits inositol monophosphate, to decrease PIP2, IP3 and DAG

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2
Q

side effects of Lithium

A

chronic interstitial nephritis

tremor

Nephrogenic DI

Teratotgen

Cardiac abnormalities

Hypothyroidism/ Goiter

worsened psoriasis

acne

leukocytosis

hair thinning

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3
Q

contraindications of Lithium

A

renal insufficiency

Hypovolemia

Low GFR/ Elderly

Pregnancy

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4
Q

which drugs cause an increase in renal lithium concentrations

A

thiazides

NSAIDS

ACE inhibitors

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5
Q

which drugs cause a decrease in renal lithium concentrations

A

Potassium-sparing diuretics

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6
Q

which drugs alter renal lithium levels

A

Loop Diuretics can cause an increase or decrease in lithium levels

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7
Q

indications of Lithium

A

Bipolar disorder

acute mania

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8
Q

indications of antipsychotics

A

positive schizophrenia symptoms

psychosis

mania

bipolar

OCD

Tourette syndrome

Huntington Disease

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9
Q

what do typical (first generation) antipsychotics usually end with

A

-azine

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10
Q

what do atypical (2nd generation) antipsychotics usually end with

A
  • idone
  • apine
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11
Q

what are high potency typical antipsychotics known for

A

Extrapyramidal symptoms- symptoms affecting the basal ganglia, causing movement disorders:

dystonia: stiffness and spasm

akathisia: restlessness and urge to move

Bradykinesia

Tardive dyskinesia: choreoathetosis, lip-smacking, grimacing

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12
Q

why are extrapyramidal symptoms more pronounced in high potency typical antipsychotics?

A

D2>A2>5HT>H1

when D2 receptors are antagonized, neurotransmitters won’t be released from the caudate, leading to movement disorders

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13
Q

What are Dopamine antagonist symptoms

A

Extrapyramidal signs

hyperprolactinemia

galactorrhea

amenorrhea

anti-emetic actions

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14
Q

what are histamine antagonist symptoms

A

sedation

constipation

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15
Q

what are muscarinic antagonist symptoms

A

dry mouth

constipation

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16
Q

what are alpha-1 antagonist symptoms

A

hypotension

17
Q

which antipsychotics have more antimuscarinic symptoms and why

A

Low potency typical antipsychotics

A1= 5HT> D2

18
Q

most serious side effect of all antipsychotics

(what does it look like and what is its antagonist)

A

Neuroleptic malignant syndrome

increased CK

fever

rigidity

rhabdomyolysis

Dantrolene or Bromocriptine

19
Q

which high potency typical antipsychotic shows prolonged QT intervals

A

Haloperidol

20
Q

Chlorpromazine

class

specific side effects

A

low potency typical antipsychotic

corneal deposits

21
Q

Thioridazine

class

specific side effects

A

low potency typical antipsychotic

retinal deposits

browning of vision

22
Q

why are second-generation (atypical) antipsychotics thought to be better at treating psychosis

A

5HT>D2 blocking

23
Q

which atypical antipsychotics have the greatest anticholinergic effects and highest risk of metabolic syndrome

A

Clozapine

Olanzapine

Quetiapine

24
Q

which atypical antipsychotics cause abnormal thermal regulation

A

Olanzapine

Risperidone

25
Q

which atypical antipsychotics cause hyperprolactinemia

A

Risperidone

Amisulpride

Paliperidone

26
Q

which atypical antipsychotics are associated with prolonged QT

A

Ziprasidone

Iloperidone

27
Q

Aripiprazole

MOA

class

side effects

A

atypical antipsychotic

partial D2 agonist- less dopamine blockade adverse effects

causes: akathisia

28
Q

Clozapine

class

MOA

specific side effects

A

class: atypical antipsychotic

MOA: a1>5HT>D2

specific side effects: agranulocytosis, seizures, cardiac abnormalities, anticholinergic effects, metabolic syndrome

29
Q

Olanzapine

class

MOA

specific side effects

A

class: atypical antipsychotic

MOA: 5HT>H1>D2>a1

specific side effects: elevated LFTs, orthostatic hypotension, anticholinergic effects, metabolic syndrome

30
Q

Quetiapine

class

specific side effects

A

class: atypical antipsychotic

specific side effects: anticholinergic effects, metabolic syndrome, sedation

31
Q

what is metabolic syndrome and what antipsychotics do you see it in

A

presence of the following symptoms: weight gain, hyperglycemia, dyslipidemia

Clozapine

Olanzapine

Quetiapine

Behavior (11 decks)

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