Antipsychotics- Second generation (atypical)

Question 1

What are they indicated for?

Answer 1

Schizophrenia particularly if extrapydramidal side effects of fist-generation occur

Bipolar disorder

Question 2

What drug in this class is more effective in refractory schizophrenia?

Answer 2

Clozapine

Question 3

How do they work?

Answer 3

Block post-synaptic dopamine D2 receptors

Question 4

What are the side effects of these drugs in the class?

Answer 4

More tolerated than first generation.

Less common drowsiness and cognitive impairment

Weight gain

Diabetes mellitus

Lipid changes

Prolong QT interval

Question 5

What side effects can occur with risperidone?

Answer 5

Affect regulation of prolactin causing breast symptoms in men and women

Sexual dysfunction

Question 6

What side effects occur with clonzapine?

Answer 6

Severe deficiency of neutrophils (agranulocytosis

Myocarditis

Question 7

What are the warnings of this drug class?

Answer 7

Caution in cardiovascular disease

Question 8

What must clozapine not be used in?

Answer 8

severe heart disease or people with a history of neutropenia

Question 9

What drugs do they interact with?

Answer 9

Sedation can be more pronounced when used with other sedating drugs

Should not be combined with antiemetics that block dopamine D2 receptors

Should not be used with drugs that prolong QT interval