Dopaminergic drugs for Parkinson’s disease Flashcards
What are the indicated for?
Improve motor symptoms in Parkinson’s disease
secondary parkinsonism
How do they work?
Increase dopaminergic stimulation
What are the side effects of this drug class?
Nausea
Hypotension
What side effects are more common in dopamine agonists?
Sleepiness
Confusion
Hallucinations
What side effect are more common in Levodopa?
Involuntary movements (dyskinesias)
Wearing-off effect
What are the warnings of drugs in this class?
Caution in elderly and those with existing cognitive and psychiatric disease
Caution in cardiovascular disease
What drugs interact with these drugs?
Peripheral dopa-decarboxylase inhibitor reduce conversion of levedopa to dopamine outside the brain
Should not usually be combined with first-generation antipsychotics and to less extent secondary or metoclopramide as they have opposing effects
