Antiretroviral Therapy Flashcards
(18 cards)
Which NRTIs absorption is affected by food?
Didanosine
Stavudine
What is the backbone of ART? That must be present with other drugs
NRTIs
The ART suitable for pregnancy is……
Zidovudine
The half life of phosphorylated zidovudine is ……….
3-4 hours
The percentage absorption of zidovudine is …… and distribute into CSF
63% orally absorbed
60-65% of serum in the CSF
ART that is most suitable for HIV pregnant px and post exposure prophylaxis is ……….
Zidovudine
Lipoatrophy and insulin resistance is a common side effects in which ARTs?
Thymidine derivatives
Zidovudine
What is the first ART to be introduced …………
Zidovudine
1987
Lamivudine and emtricitabine rapidity select ……. mutation
M184 mutation
M184V mutation confers reduced susceptibility to which drugs
Emtricitabine
Lamivudine
Abacavir
Diadanosine
Zalcitabine
M184V resistance can make the virus more susceptible to …….
Zidovudine
K65R causes reduced susceptibility to……
Tenofovir
Lamivudine
Emtricitabine
Abacavir
Lipoatrophy and resistance is common with ……… and rare with ……
Common with zidovudine and stovudine
K65R resistant ART
Why are lamivudine and emtricitabine never used as a monotherapy except in pre or post-prophylaxis
Because they are rapidly selective for M184V mutation
And K65R
Screening for HLA ……. is important in Hypersensitivity reaction in Abacavir
HLA B5701
