Antiretrovirals

Question 1

NRTIs

Answer 1

nucleoside OR nucleotide reverse transcriptase inhibitors

Question 2

NNRTIs

Answer 2

non-nucleoside reverse transcriptase inhibitors

Question 3

PIs

Answer 3

protease inhibitors

Question 4

MOA of NRTIs

Answer 4

incorporates into growing HIV viral DNA strand by reverse transcriptase - terminating synthesis

Question 5

What are the possible AE of NRTIs?

Answer 5

Lactic acidosis

Hepatomegaly w/steatosis

Question 6

What class of drug is zidovudine?

Answer 6

NRTI

Question 7

What class of drug is lamivudine?

Answer 7

NRTI

Question 8

What class of drug is emtricitabine?

Answer 8

NRTI

Question 9

What class of drug is didanosine?

Answer 9

NRTI

Question 10

What class of drug is stavudine?

Answer 10

NRTI

Question 11

What class of drug is abacavir?

Answer 11

NRTI

Question 12

What class of drug is tenofovir?

Answer 12

NRTI

Question 13

Lamivudine + zidovudine

Answer 13

combivir

NRTI

Question 14

Abacavir + lamivudine + zidovudine

Answer 14

trizivir

NRTI

Question 15

Tenofovir + emtricitabine

Answer 15

truvada

NRTI

Question 16

Abacavir + lamivudine

Answer 16

epzicom

NRTI

Question 17

Tenofovir + emtricitabine + efavirenz

Answer 17

atripla

NRTI

Question 18

MOA of NNRTIs

Answer 18

directly bind to reverse transcriptase to inhibit transcription

Question 19

Which class of drug, NRTI or NNRTIs do NOT require phosphorylation to be active?

Answer 19

NNRTIs

Question 20

What class of drug is delavirdine?

Answer 20

NNRTI

Question 21

What class of drug is nevirapine?

Answer 21

NNRTI

Question 22

What class of drug is Efavirenz?

Answer 22

NNRTI

Question 23

What is an AE of efanvirenz?

Answer 23

vivid dreams, drowsiness or insomnia

Question 24

MOA of protease inhibitors

Answer 24

bind to protease preventing the cleavage and inhibitor the assembly of new HIV viruses

Question 25

With what class of drug may you have hypercholesterimia or insulin resistance?

Answer 25

Protease inhibitors

Question 26

What can you treat the PI induced hyperchloresterimia with?

Answer 26

fibric acid derivatives | HMG-CoA reductase inhibitor (statins)

Question 27

In what type of pt are NRTIs contraindicated?

Answer 27

kidney disease

Question 28

What class of drug is enfuvirtide?

Answer 28

Fusion inhibitor | fuzeon

Question 29

What class of drug is marviroc?

Answer 29

chemokine receptor antagonists

Question 30

At what sites does marviroc bind?

Answer 30

CCR5 | CXCR4

Question 31

At what site does marviroc block viral entry?

Answer 31

CCR5

Question 32

What class of drug is raltegravir?

Answer 32

integrase inhibitors

Question 33

What drug is metabolized by UGT1A1 (glucuronidation)?

Answer 33

raltegravir | integrase inhibitor

Question 34

What class of drug has no induction or inhibition on CYPP450 enzymes or Pgp?

Answer 34

Integrase inhibitors

Question 35

What type of drug should you not combine with protease inhibitors?

Answer 35

PPIs

Question 36

What PI is safe to combine with a PPI if administered w/RTV?

Answer 36

indinavir

Question 37

What should you not combine with rifampin?

Answer 37

PIs

Question 38

What two drugs should you avoid using with ritonavir?

Answer 38

fluticasone | alfuzosin