Antivirals

Question 1

What are the oral agents used for HSV and VZV?

Answer 1

acyclovir
valacyclovir
famciclovir

Question 2

What are the topical agents used for HSV and VZV?

Answer 2

acyclovir
docosanol
penciclovir

Question 3

What is the ophthalmic agent used for HSV and VZV?

Answer 3

trifluridine

Question 4

MOA of acyclovir

Answer 4

inhibition of viral synthesis
thymidine kinase
competes w/deoxyguanosine triphosphate

Question 5

What drug is a guanosine analog?

Answer 5

acyclovir

Question 6

What is the DOC for visceral, disseminated or CNS infx of herpes?

Answer 6

acyclovir

b.c it can go to stomach

Question 7

What are the AE of acyclovir?

Answer 7

GI symptoms

HA

Question 8

What drug is a cyclic guanine analog?

Answer 8

famciclovir

Question 9

What is an AE of famciclovir?

Answer 9

elevated LFTs

Question 10

What are the mechanisms of resistance for acyclovir?

Answer 10

reduction/absence/alteration of TK

alterations of DNA polymerase

Question 11

With what two drugs does acyclovir have cross resistance?

Answer 11

famciclovir

valacyclovir

Question 12

What are penciclovir and docosanol used to treat?

Answer 12

orolabial herpes

Question 13

What drug is used to treat orolabial herpes?

Answer 13

penciclovir

docosanol

Question 14

What class of drug is ganciclovir?

Answer 14

anti CMV agent

Question 15

What class of drug is valganciclovir?

Answer 15

anti CMV agent

Question 16

What class of drug is foscarnet?

Answer 16

anti CMV agent

Question 17

What class of drug is cidofovir?

Answer 17

anti CMV agent

Question 18

MOA of ganciclovir

Answer 18

competes w/deoxyguanosine triphosphate

interupts formation of DNA

Question 19

Which anti CMV drug is available in oral, IV and intraocular formulations?

Answer 19

ganciclovir

Question 20

Which anti CMV drug is also active against the human herpesvirus 6?

Answer 20

ganciclovir

Question 21

What is the MC AE of ganciclovir?

Answer 21

reversible pancytopenia

Question 22

Which of the anti CMV agents does NOT require thymine kinase?

Answer 22

foscarnet

Question 23

In a pt w/acyclovir resistance, what other drug can you treat them with? Why?

Answer 23

foscarnet b/c it doesnt require TK

Question 24

What is the MC AE of foscarnet?

Answer 24

renal dysfunction

Question 25

MOA of cidofovir

Answer 25

incorporation into viral DNA chain resulting in reduction of the rate of viral DNA synthesis

Question 26

Which anti CMV drug is an acyclic nucleoside phosphonate derivative?

Answer 26

cidofovir

Question 27

Which anti CMV drug also has activity against papilloma virus, polyomavirus, poxvirus and adenovirus?

Answer 27

cidofovir

Question 28

What is a major AE of cidofovir?

Answer 28

renal dysfunction (like foscarnet)

Question 29

What must be given when administering cidofovir?

Answer 29

adequate hydration | probenecid

Question 30

What anti CMV drug must be given w/probenecid?

Answer 30

cidofovir

Question 31

What is probenecid usually used to treat?

Answer 31

gout

Question 32

Which requires a longer duration of treatment, CMV or herpes virus?

Answer 32

CMV

Question 33

What are the drugs used to treat hep B

Answer 33

``` interferon alfa peginterferon entecavir adefovir telbivudine lamivudine/emtricitabine tenofovir ```

Question 34

What type of drug induces enzyme activities that promote an antiviral state?

Answer 34

interferons

Question 35

Are interferons virucidal or virustatic?

Answer 35

neither

Question 36

What is interferon alfa primarily used to treat?

Answer 36

HBV

Question 37

How is hep B MC transmitted?

Answer 37

sexually

Question 38

How is hep B MC transmitted?

Answer 38

IVDU | infusions

Question 39

What drug in high doses has been shown to be effective against kaposi's?

Answer 39

interferon alfa

Question 40

What drug has been used to treat SARS coronavirus?

Answer 40

interferon alfa

Question 41

Interferon alfa is good at preventing respiratory viruses with the exception of what virus?

Answer 41

adenovirus

Question 42

What class of drug is adefovir dipivoxil?

Answer 42

antiviral

Question 43

With what can you treat HBV that is resistant to lamivudine and entecavir?

Answer 43

adefovir dipivoxil

Question 44

What drugs are used to treat hep C?

Answer 44

``` ribavirin pegylated interferon (also hep b) ```

Question 45

What is ribavirin often used to treat?

Answer 45

hep C

Question 46

What drug is a purine nucleoside analog?

Answer 46

ribavirin

Question 47

In what forms is ribavirin available?

Answer 47

orally | inhalation

Question 48

Which drug may also be effective against hemorrhagic fever, lassa fever and hantaan virus?

Answer 48

ribavirin

Question 49

What is the major AE of ribavirin?

Answer 49

hemolytic anemia

Question 50

What are the drugs used to treat influenzae?

Answer 50

oseltamivir zanamivir amantadine rimatadine

Question 51

What is oseltamivir often used to treat?

Answer 51

influenzae

Question 52

What is zanamivir often used to treat?

Answer 52

influenzae

Question 53

What is amantadine often used to treat?

Answer 53

influenzae

Question 54

What is rimantadine often used to treat?

Answer 54

influenzae

Question 55

In what form is zanamivir often given?

Answer 55

inhalation

Question 56

What is the spectrum of zanamivir?

Answer 56

avian influenza and H5N1 (plus the other flus)

Question 57

What is the MOA of amantadine and rimantadine?

Answer 57

prevents release of viral nucleic acid into host cell

Question 58

What drugs are used to treat papillomavirus?

Answer 58

``` imiquimod podofilox trichloroacetic acid podophyllin cryotherapy ```

Question 59

What is trichloroacetic acid often used to treat?

Answer 59

papillomavirus

Question 60

What is the gold standard for the treatment of papillomavirus?

Answer 60

imiquimod

Question 61

Which drug is AKA podophyllotoxin?

Answer 61

podofilox

Question 62

Which anti papillomavirus drug is a keratolytic agent?

Answer 62

trichloroacetic acid

Question 63

Which anti papillomavirus drug is available in a powder form?

Answer 63

trichloroacetic acid